Updated: 2018-07-23    Read：

Basic Information

Teacher Name : Zhe Ma

Job Title: Associate Professor

Phone： 025-84395057

Email：mazhe@njau.edu.cn

Address：1 Tongwei street, Nanjing, JS, China, 210095

Research Areas and Descriptors：

My major findings include identified new virulent factor in pathogenic Streptococcus equi ssp. zooepidemicus (SEZ) through genomics, transcriptomic and proteomics; identified host proteins interact with these virulence factors; clarified the signal transduction in host epithelial cells and immune cells during SEZ infection, especially the small GTPase related signal pathway; developed salmonella diseases serological diagnostic approach. I have published 19 SCI papers and I am the first author or corresponding author in 9 of these papers. I have gained 5 grants from the government, 4 of them are supported by the nation. Total funding is ¥1,610,000.

I am a veterinarian-scientist active in laboratory investigation, translational research, institutional service, and training of students.  These activities occur at NJAU and flow mainly through my focus on studying the molecular pathogenesis of streptococcus.

Profiles

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Peer-reviewed publications in print or other media

 § Research investigations

1. Z. Ma, H. Fan* and C. Lu. "Molecular cloning and analysis of the UDP-Glucose Pyrophosphorylase in Streptococcus equi subsp. zooepidemicus." Mol Biol Rep, 2011, 38(4): 2751-2760.

2. Z. Ma, J. Geng, H. Zhang, H. Yu, L. Yi, M. Lei, C. Lu, H. Fan* and S. Hu*. "Complete genome sequence of Streptococcus equi subsp. zooepidemicus strain ATCC 35246." J Bacteriol, 2011, 193(19): 5583-5584.

3. Z. Ma, H. Zhang, J. Zheng, Y. Li, L. Yi, H. Fan* and C. Lu. "Interaction between M-Like Protein and Macrophage Thioredoxin Facilitates Antiphagocytosis for Streptococcus equi ssp. zooepidemicus." PLoS One, 2012, 7(2): e32099.

4. Z. Ma, H. Zhang, L. Yi, H. Fan* and C. Lu. "Microarray Analysis of the Effect of Streptococcus equi subsp. zooepidemicus M-Like Protein in Infecting Porcine Pulmonary Alveolar Macrophage." PLoS One, 2012, 7(5): e36452.

5. H. Lin, Z. Ma, H. Fan*, C. Lu. "Construction and immunogenicity of recombinant swinepox virus expressing capsid protein of PCV2. " Vaccine, 2012, 30, 6307-6313.

6. Z. Ma, J. Geng, L. Yi, B. Xu, R. Jia, Y. Li, Q. Meng, H. Fan* and S. Hu*. "Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246." BMC Genomics, 2013, 14: 377.

7. L. Yi, Y. Wang, Z. Ma, H. Zhang, Y. Li, J. Zheng, Y. Yang, C. Lu and H. Fan*. "Contribution of fibronectin-binding protein to pathogenesis of Streptococcus equi ssp. zooepidemicus. " Pathogens and disease, 2013, 67, 174-183.

8. H. Zhou, Z. Ma, J. Yuan, H. Fan*. "Identification and Characterization of Putative Virulent Genes in Streptococcus equi ssp. zooepidemicus. " Journal of Integrative Agriculture, 2013, 12, 101-108.

9. H. Zhang, Z. Ma, Y. Li, J. Zheng, L. Yi, H. Fan* and C. Lu. "Identification of a novel collagen type capital I-binding protein from Streptococcus suis serotype 2. " Vet J, 2013, 197, 406-414.

10. L. Yi, Y. Wang, Z. Ma, H. Zhang, H. Xie, Y. Yang, C. Lu and H. Fan*. "Identification of genes transcribed by Streptococcus equi ssp. zooepidemicus in infected porcine lung. " Microb Pathog, 2013, 59-60, 7-12.

11. Y. Yang, Y. Liu, Y. Ding, L. Yi, Z. Ma, H. Fan* and C. Lu. "Molecular characterization of Streptococcus agalactiae isolated from bovine mastitis in Eastern China. " PLoS One, 2013, 8, e67755.

12. H. Zhang, J. Zheng, L. Yi, Y. Li, Z. Ma, H. Fan* and C. Lu. "The identification of six novel proteins with fibronectin or collagen type I binding activity from Streptococcus suis serotype 2. " J Microbiol, 2014, 52, 963-969.

13. L. Yi, Y. Wang, Z. Ma, H. Zhang, Y. Li, J. Zheng, Y. Yang, H. Fan* and C. Lu. "Biofilm formation of Streptococcus equi ssp. zooepidemicus and comparative proteomic analysis of biofilm and planktonic cells. " Curr Microbiol, 2014, 69, 227-233.

14. H. Lin, Z. Ma, X. Yang, H. Fan* and C. Lu. "A novel vaccine against Porcine circovirus type 2 (PCV2) and Streptococcus equi ssp. zooepidemicus (SEZ) co-infection. " Vet Microbiol, 2014, 171, 198-205.

15. Z. Ma, L. Yu, H. Zhou, T. Liu, B. Xu, F. Ma, J. Peng and H. Fan*. "Identification of novel genes expressed during host infection in Streptococcus equi ssp zooepidemicus ATCC35246." Microbial Pathogenesis, 2015, 79: 31-40.

16. R. Liu, P. Zhang, Y. Su, H. Lin, H. Zhang, L. Yu, Z. Ma*, H. Fan. "A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp. zooepidemicus gene mutation." Sci Rep, 2016, 6: 27133.

17. Z. Ma, J. Peng, H. Zhang, B. Xu, X. Pei, H. Lin, C. Lu, H. Fan*. "SILAC and LC-MS/MS identification of Streptococcus equi ssp. zooepidemicus proteins that contribute to mouse brain microvascular endothelial cell infection." Appl Microbiol Biotechnol, 2016.

18. L. Yi, Y. Wang, Z. Ma, H. Lin, B. Xu, D. Grenier, H. Fan* and C. Lu. "Identification and characterization of a Streptococcus equi ssp. zooepidemicus immunogenic GroEL protein involved in biofilm formation. " Vet Res, 2016, 47: 50.

19. J. Peng, Z. Ma*, C. Hua, H. Lin, H. Zhang, C. Lu and H. Fan*. "Virulent and vaccine strains of Streptococcus equi. ssp. zooepidemicus have different influences on phagocytosis and cytokine secretion of macrophages. " Journal of Proteome Research, 2017, 16(1), 77-86.

Asterisk denote corresponding author