BASIC INFORMATION
Name: Xingxiang Chen
Title: Professor
Phone：0086-25-84395507
Email：cxx@njau.edu.cnAddress：Room 313, Animal Teaching Hospital
Research Areas and Descriptors：
# Animal Nutritional Disorders
# Veterinary Internal Medicine
# Veterinary Clinical Pathology
PROFILE
EMPLOYMENT HISTORY
üProfessor, 2021.01 – Present
College of Veterinary Medicine, Nanjing Agricultural University, China
üAssociate Professor, 2015.07 – 2020.12
College of Veterinary Medicine, Nanjing Agricultural University, China
üLecturer, 2012.07 – 2015.06
College of Veterinary Medicine, Nanjing Agricultural University, China
üResearcher, 2002.08 – 2009.07
Institute of Veterinary Medicine, Jiangsu Academy of Agriculture Science, China
EDUCATION & TRAINING
üVisitor, 2016.03 – 2017.03
Institute for Cell and Molecular Biosciences, Newcastle University, United Kingdom
üVisitor, 2013.07 – 2013.10
Institute for Cell and Molecular Biosciences, Newcastle University, United Kingdom
üPh.D., 2009.09 – 2012.07
Nanjing Agricultural University, China, major in veterinary.
üM.S., 1999.09 – 2002.07
Nanjing Agricultural University, China, major in veterinary.
üB.S., 1995.09 – 1999.07
Nanjing Agricultural University, China, major in veterinary.
TEACHING EXPERIENCE
üAnimal Nutritional Disorders
üVeterinary Clinical Diagnostics
üVeterinary Internal Medicine
SELECTED RESEARCH GRANTS
üXingxiang Chen (PI), 2023.01-2026.12. The study of RIP1/RIP3/MLKL-mediated necroptosis pathway in FB1-induced porcine pulmonary edema via vascular endothelium injury (32273081). The National Natural Science Foundation of China.
üXingxiang Chen (PI), 2020.01-2023.12. The study of pyroptosis pathway in porcine intestinal inflammation caused by DON and FB1 alone or combined exposure (31972745). The National Natural Science Foundation of China.
üXingxiang Chen (PI), 2018.03-2020.04. Role of apoptosis in persistent PCV2 infection and replication promoted by oxidative-stress-induced autophagy (31811530300). The National Natural Science Foundation of China.
üXingxiang Chen (PI), 2017.07-2020.06. The Development and application of selenium-zinc-enriched probiotics in companion animals (2017YFD0501001). National Key Research and Development Program.
üXingxiang Chen (PI), 2016.07-2020.06. The Integration and Demonstration of Prevention and Control Technology for the Imbalance of Trace Elements, Vitamins and Electrolytes in Cattle and Sheep (2016YFD0501203). National Key Research and Development Program.
üXingxiang Chen (PI), 2015.01-2018.12. The autophagy mechanism in the PCV2 replication promotion induced by oxidative stress and its nutritional regulation (31472252). The National Natural Science Foundation of China.
SELECTED PUBLICATIONS(*CORRESPONDING AUTHOR)
1)Mao X, Zhang P, Du H, Ge L, Liu S, Huang K,Chen X*. The combined effect of Deoxynivalenol and Fumonisin B1 on small intestinal inflammation mediated by pyroptosis in vivo and in vitro. Toxicol Lett. 2022 Oct 26:S0378-4274(22)01766-0. doi: 10.1016/j.toxlet.2022.10.007. Online ahead of print.
2)Qu J, Liu K, Liu S, Yue D, Zhang P, Mao X, He W, Huang K,Chen X*. Taurine alleviates ochratoxin A-induced pyroptosis in PK-15 cells by inhibiting oxidative stress. J Biochem Mol Toxicol. 2022 Oct 24:e23249. doi: 10.1002/jbt.23249. Online ahead of print.
3)Qu J, Zhang S, He W, Liu S, Mao X, Yin L, Yue D, Zhang P, Huang K,Chen X*. Crucial Function of Caveolin-1 in Deoxynivalenol-Induced Enterotoxicity by Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis. J Agric Food Chem. 2022 Oct 12; 70(40):12968-12981.
4)Zhang P, Li B, Mu J, Liu D, Zhang G, Mao X, Huang K, Waldron KJ,Chen X*. The therapeutic and preventive effects of a canine-origin VB 12 -producing Lactobacillus on DSS-induced colitis in mice. J Anim Physiol Anim Nutr (Berl). 2022 Aug 31. doi: 10.1111/jpn.13767. Online ahead of print.
5)Mao X, Liu S, Ge L, Du H, Yue D, Hou L, Huang K,Chen X*. mTOR-Mediated Autophagy Regulates Fumonisin B1-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro. J Agric Food Chem. 2022 Jul 27;70(29):9187-9200.
6)Mao X, Li H, Ge L, Liu S, Hou L, Yue D, Du H, Pan C, Gan F, Liu Y, Huang K,Chen X*. Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells. J Biochem Mol Toxicol. 2022, 36(1):e22933.
7)Kai Liu, Dongmei Yue, Xinru Mao, Hu Li, Jie Qu, Shuiping Liu, Viktor I. Korolchuk, Yunhuan Liu, Fang Gan, Cuiling Pan, Kehe Huang,Xingxiang Chen*. Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro, Ecotoxicology and Environmental Safety, 2021, 228:113050.
8)Li H#, Mao X#, Liu K, Sun J, Li B, Malyar RM, Liu D, Pan C, Gan F, Liu Y, Huang K,Chen X*. Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis. Arch Toxicol, 2021, 95(4):1489-1502.
9)Malyar RM, Naseri E, Li H, Ali I, Farid RA, Liu D, Maroof K, Nasim M, Banuree SAH, Huang K, Waldron KJ,Chen X*. Hepatoprotective Effects of Selenium-Enriched Probiotics Supplementation on Heat-Stressed Wistar Rat Through Anti-Inflammatory and Antioxidant Effects. Biol Trace Elem Res. 2021, 199(9):3445-3456.
10)Mao X, Fu C, Liu K, Li H, Malyar RM, Li B, Pan C, Gan F, Huang K,Chen X*. Effects of Glycerol-Producing Yeast Supplementation on Production Performance, Biochemical Indexes, Subclinical Ketosis Incidence and Rumen Fermentation Performance of Dairy Cows. Int J Nutr Sci. 2021; 6(1): 1049.
11)Liu K, Mao X, Li H, Liu D, Le G, Gan F, Pan C, Huang K,Chen X*. Regulation of taurine in OTA-induced apoptosis and autophagy. Toxicon. 2020 Jul 15;181:82-90. doi: 10.1016/j.toxicon.2020.04.097.
12)Malyar RM, Li H, Liu D, Abdulrahim Y, Farid RA, Gan F, Ali W, Enayatullah H, Banuree SAH, Huang K,Chen X*. Selenium/Zinc-Enriched probiotics improve serum enzyme activity, antioxidant ability, inflammatory factors and related gene expression of Wistar rats inflated under heat stress. Life Sci. 2020 May 1;248:117464. doi: 10.1016/j.lfs.2020.117464. Epub 2020 Feb 22.
13)Li H, Malyar RM, Zhai N, Wang H, Liu K, Liu D, Pan C, Gan F, Huang K, Miao J,Chen X*. Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins. Life Sci. 2019, 234:116735.
14)Mohammad Malyar R, Li H, Enayatullah H, Hou L, Ahmad Farid R, Liu D, Akhter Bhat J, Miao J, Gan F, Huang K,Chen X*. Zinc-enriched probiotics enhanced growth performance, antioxidant status, immune function, gene expression, and morphological characteristics of Wistar rats raised under high ambient temperature. 3 Biotech. 2019, 9(8):291.
15)Zhai N, Liu K, Li H, Liu Z, Wang H, Korolchuk VI, Carroll B, Pan C, Gan F, Huang K,Chen X*. PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis. Vet Res. 2019, 50(1):19.
16)Chen X, Xu J, Liu D, Sun Y, Qian G, Xu S, Gan F, Pan C, Huang K*. The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy. Chem Biol Interact. 2019, 300:27-34.
17)Zhai N, Wang H, Chen Y, Li H, Viktor K, Huang K,Chen X*. Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent autophagy via inhibiting AMPK/mTOR signaling pathway. Chem Biol Interact. 2018, 296:220-228.
18)Qian Gang, Liu Dandan, Hu Junfa, Gan Fang, Hou Lili, Zhai Nianhui,Chen Xingxiang*, Huang Kehe*. SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway. Vet Res, 2018, 49(1): 15.
19)Liu Dandan, Xu Jing, Qian Gang, Hamid Mohammed, Gan Fang,Chen Xingxiang*, Huang Kehe*. Selenizing astragalus polysaccharide attenuates PCV2 replication promotion caused by oxidative stress through autophagy inhibition via PI3K/AKT activation. Int J Biol Macromol, 2018, 108: 350~359.
20)Qian Gang, Liu Dandan, Hu Junfa, Gan Fang, Hou Lili,Chen Xingxiang*, Huang Kehe *, Ochratoxin A-induced autophagy in vitro and in vivo promotes porcine circovirus type 2 replication. Cell Death & Disease, 2017, 8: e2909.
21)Chen Xingxiang, Che Chaoping, Korolchuk Viktor, Gan Fang, Pan Cuiling, Huang Kehe*, Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression. Journal of Agricultural and Food Chemistry, 2017, 65(12): 2495~2502.
22)Zheqian Zhang, Fang Gan, Hongxia Xue, Yunhuan Liu, Da Huang, Alam Zeb Khan,Xingxiang Chen*, Kehe Huang*. Nephropathy and hepatopathy in weaned piglets provoked by natural ochratoxin A and involved mechanisms. Experimental and Toxicologic Pathology, 2016, 68(4): 205~213.
23)Chen Xingxiang, Shi Xiuli, Gan Fang, Huang Da, Huang Kehe*. Glutamine starvation enhances PCV2 replication via the phosphorylation of p38 MAPK, as promoted by reducing glutathione levels . Veterinary Research, 2015, 46:32.
24)Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang, Huang Kehe*. Interaction of porcine circovirus type 2 replication with intracellular redox status in vitro. Redox Rep, 2013, 18(5): 186~192.
25)Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang, Huang Kehe*. Selenium blocks porcine circovirus type 2 replication promotion induced by oxidative stress by improving GPx1 expression. Free Radical Biology and Medicine, 2012.8.1, 53(3): 395~405.
26)Chen Xingxiang, Ren Fei, Hesketh John, Shi Xiuli, Li Junxian, Gan Fang, Huang Kehe*. Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-kappaB pathway. Virology, 2012.4.25, 426(1): 66~72.
HONORS, AWARDS, AND SCHOLARSHIPS
1)Chen Xingxiang, Interaction among PCV2 infection, oxidative stress and selenium and their mechanism. Outstanding Doctoral Dissertation of Jiangsu Province: 2013, Jiangsu Province, P. R. China.
2)Huang K, Lu k, Zhang K, Pan C,Chen X, Qun S. Development of new biological feed additives with multifunction and their applications. The outstanding achievements in scientific research of Higher School Award: 2012, Ministry of Education of China.
- Updated at November 2022 -
