Hongjie Fan
Address:
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Tel:+86 25 84396219
Fax:+86 25 84396219
Email: fhj@njau.edu.cn
Positions Held:
President of the College of Veterinary Medicine, Nanjing Agricultural University
Professor of Preventive veterinary medicine, College of Veterinary Medicine, Nanjing Agricultural University
Education:
• Ph.D. in Preventive veterinary medicine, College of Veterinary Medicine, Nanjing Agricultural University, 2003
• M.S. in Preventive veterinary medicine, College of Veterinary Medicine, Yangzhou University, 1996
• B.S. in Veterinary medicine, Anhui Science and TechnologyCollege, 1990
Research:
•Veterinary Microbiology and Immunology
•Veterinary Public Health
Awards:
•State Science and Technology Awards, the State Council, 2007
•TheState-level Teaching Award, the ministry of education, 2014
•Outstanding talents in agricultural scientific research, the Ministry of Agriculture, 2015
•TheJiangsu special Professor, the Jiangsu provincial government, 2013
Grant Proposals:
•National Key Research and Development Program of China, 2018-2020
•National Key Research and Development Program of China, 2017-2020
•National Natural Science Foundation of China, 2017-2020
•Special Fund for Agro-scientific Research in the Public Interest, 2014-2018
•National Transgenic Major Program, 2014-2016
•National Natural Science Foundation of China, 2013-2016
•National Basic Research Program (973) of China, 2012-2016
•National Natural Science Foundation of China, 2013-2015
•Jiangsu AgriculturalScience and Technology Innovation Fund, 2012-2014
•Jiangsu Province Science and Technology Support Program, 2009-2012
•National Transgenic Major Program, 2009-2011
•National Natural Science Foundation of China, 2008-2010
•National Natural Science Foundation of China, 2007-2007
Publications:
1. Liu Rui, Li Weiyi, Fan Hongjie*. The serine/threonine protein kinase of Streptococcus suis serotype 2 affects the ability of the pathogen to penetrate the blood brain barrier. Cellular Microbiology, 2018, 24:e12862
2. Ma Zhe, Yang Xinyi, Fan Hongjie*. Detection of Salmonella infection in chickens by an indirect enzyme-linked immunosorbent assay based on presence of PagC antibodies in sera. Foodborne Pathogens and Disease, 2017, 1(12)
3. Yuan Xiaomin, Lin Huixing, Fan Hongjie*. Swinepox virus vector‑based vaccines: attenuation and biosafety assessments following subcutaneous prick inoculation. Veterinary Research, 2018,49:14
4. Jiang Hui, Fan Hongjie∗, Ding Jiabo∗. Transcriptome analysis of gene expression profiling of infected macrophages between Brucella suis 1330 and live attenuated vaccine strain S2 displays mechanistic implication for regulation of virulence. Microbial Pathogenesis, 2018, 119:241–247
5. Zhu Yuanyuan, Fan Hongjie*, Zhao Qizu*. Insertion site of FLAG on foot-and-mouth disease virus VP1 G-H loop affects immunogenicity of FLAG. Journal of Integrative Agriculture 2018, 17: 60345-60357
6. Fan Hongjie*. Advances in pathogenesis of Streptococcus suis serotype 2. Journal of Integrative Agriculture, 2017, 16(12): 2834–2847
7. Xu Bin, Zhang Ping, Fan Hongjie*. hsdS, Belonging to the Type I Restriction-Modification System, Contributes to the Streptococcus suis Serotype 2 Survival Ability in Phagocytes. Frontiers in Microbiology, 2017, 8:1524
8. Yuan Xiaomin, Lin Huixing, Fan Hongjie*. Efficacy and immunogenicity of recombinant swinepox virus expressing the truncated S protein of the novel isolated porcine epidemic diarrhea virus strain. Archives of Virology, 2017, 7:1-11
9. Peng Jie, Ma Zhe, Fan Hongjie*. Virulent and vaccine strains of Streptococcus equi ssp. zooepidemicus have different influences on phagocytosis and cytokine secretion of macrophages. Journal of Proteome Research, 2017, 16:77-86
10. Ma Fang, Ma Zhe, Fan Hongjie*. Streptococcus suis Serotype 2 Biofilms Inhibit the Formation of Neutrophil Extracellular Traps. Frontiers in Cellular and Infection Microbiology, 2017, 7: 86
11. Ma Fang, Guo Xiao, Fan Hongjie*. Extracellular Nucleases of Streptococcus equi subsp. zooepidemicus Degrade Neutrophil Extracellular Traps and Impair Macrophage Activity of the Host. Applied and Environmental Microbiology, 2017, 83(2): e02468-16
12. Lin Huixing, Ma Zhe, Fan Hongjie*. Construction and immunogenicity of a recombinant swinepox virus expressing a multi-epitope peptide for porcine reproductive and respiratory syndrome virus. Scientific Reports, 2017, 7:43990
13. Lin Huixing, Li Bin, Fan Hongjie*. Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection. Journal of Proteome Research, 2017, 16: 2113-2120
14. Lin Huixing, Ma Zhe, Fan Hongjie*. Recombinant swinepox virus expressing glycoprotein E2 of classical swine fever virus confers complete protection in pigs upon viral challenge. Frontiers in Veterinary Science, 2017, 4:81
15. Wang Xiaomin, He Kongwang*, Fan Hongjie*. MicroRNA-30a-5p promotes replication of porcine circovirus type 2 through enhancing autophagy by targeting 14-3-3. Archives of Virology, 2017, 5:1-12
16. Liu Rui, Ma Zhe*, Fan Hongjie*. A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp zooepidemicus gene mutation. Scientific Reports, 2016, 6: 27133
17. Yi Li, Fan Hongjie*, Liu Chengping. Identification and characterization of a Streptococcus equi ssp. zooepidemicus immunogenic GroEL protein involved in biofilm formation. Veterinary Research, 2016, 47:50
18. Ma Zhe, Peng Jie, Fan Hongjie*. SILAC and LC-MS/MS identification of Streptococcus equi ssp. zooepidemicus proteins that contribute to mouse brain microvascular endothelial cell infection. Applied Microbiology and Biotechnology, 2016, 5: 1-12
19. Lin Huixing, Chen Lei, Fan Hongjie*. Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets against homologous challenge. Virology Journal, 2016, 13(68): 1-7
20. Xu Bin, Yang Xinyi, Fan Hongjie*. The arginine deiminase system facilitates environmental adaptability of Streptococcus equi ssp. zooepidemicus through pH adjustment. Research in Microbiology, 2016, 1-10
21. Xu Bin, Su Yiqi, Fan Hongjie*. Capsule of Streptococcus equi subsp zooepidemicus hampers the adherence and invasion of epithelial and endothelial cells and is attenuated during internalization. Fems Microbiology Letters, 2016, 363(16): 164
22. Zhuge Xiangkai, Dai Jianjun*, Fan Hongjie*. AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection. Scientific Reports, 2016; 6: 25085
23. Fang Yizhen, Lin Huixing, Fan Hongjie*. Construction and immunogenicity of recombinant swinepox virus expressing outer membrane protein L of Salmonella, Journal of Microbiology and Biotechnology, 2016, 26(1):1-13
24. Javed Memon, Jam Kashif, Fan Hongjie*, Serotypes, Genotypes, Virulence Factors and Antimicrobial Resistance Genes of Escherichia coli Isolated in Bovine Clinical Mastitis from Eastern China. Pakistan Veterinary Journal, 2016, 36(4):493-498
25. Yuan Xiaomin, Lin Huixing, Fan Hongjie*, Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein, Vaccine, 2015, 33:3900-3906
26. Ma Zhe, Yu Lei, Fan Hongjie*, Identification of novel genes expressed during host infection in Streptoccus equi ssp. zooepidemicus ATCC35246, Microbial Pathogenesis, 2015, 79:31-40
27. Hao Hongping, Hongjie Fan*, Xiang Mao*. LiCl inhibits PRRSV infection by enhancing Wnt/b-catenin pathway and suppressing inflammatory responses. Antiviral Research, 2015, 117: 99-109
28. Huan Changchao, Fan Hongjie*, Xiang Mao*, Porcine epidemic diarrhea virus uses cell-surface heparan sulfate as an attachment factor, Archives of Virology, 2015, 160:1621-1628
29. Ni Bo, HongJie Fan*, Xiang Mao*, The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry, Biochemical and Biophysical Research Communications, 2015, 458:392e398
30. Lin Huixing, Ma Zhe, Fan Hongjie*. A novel vaccine against Porcine circovirus type 2 (PCV2) and Streptococcus equi ssp. zooepidemicus (SEZ) co-infection, Veterinary Microbiology, 2014, 171(1-2):198-205
31. Zhang Hui, Fan Hongjie*, Lu Chengping*. The identification of six novel proteins with fibronectin or collagen type I binding activity from Streptococcus suis serotype 2, Journal of Microbiology, 2014, 52(11):963-969
32. Li Yue, Zheng Junxi, Fan Hongjie*. Effect of Tran on virulence through regulating metabolism and stress tolerance of Streptococcus suis serotype 2, Microbiology Research, 2014, 169(9):666-674
33. Yi Li, Wang Yang, Fan Hongjie*. Biofilm Formation of Streptococcus equi ssp. zooepidemicus and Comparative Proteomic Analysis of Biofilm and Planktonic Cells, Current Microbiology, 2014, 69(3):227-233
34. Ma Zhe, Fan Hongjie*, Hu Songnian*. Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp zooepidemicus strain ATCC35246, BMC Genomics, 2013, 14:1-12
35. Zhang Hui, Ma Zhe, Fan Hongjie*. Identification of a novel collagen type I-binding protein from Streptococcus suis serotype 2, The Veterinary Journal, 2013, 197(2):406-414
36. Yi Li, Wang Yang, Fan Hongjie*. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus equi ssp zooepidemicus, Pathogens and Disease, 2013, 67(3):174-183
37. Yi Li, Wang Yang, Fan Hongjie*. Identification of genes transcribed by Streptococcus equi ssp zooepidemicus in infected porcine lung, Microbial Pathogenesis, 2013, 59-60:7-12
38. Zhou Hong, Ma Zhe, Fan Hongjie*. Identification and Characterization of Putative Virulent Genes in Streptococcus equi ssp zooepidemicus, Journal of Integrative Agriculture, 2013, 12(2):327-333
39. Zheng Junxi, Li Yue, Fan Hongjie*. Identification and Characterization of a Novel Hemolysis-Related Gene in Streptococcus suis Serotype 2, PLoS One, 2013, 8(9)
40. Yang Yongchun, Fan Hongjie*, Lu Chengping. Molecular Characterization of Streptococcus agalactiae Isolated from Bovine Mastitis in Eastern China, PLOS ONE, 2013, 8(7)
41. Memon Javed, Wang Liping, Fan Hongjie*. Molecular Characterization and Antimicrobial Sensitivity of Pathogens from Sub-Clinical and Clinical Mastitis in Eastern China, Pakistan veterinary journal, 2013, 33(2):170-174
42. Zhang Zhicheng, Lu Chengping, Fan Hongjie*. Analysis of synonymous codon usage patterns in torque teno sus virus 1 (TTSuV1), Archives of Virology, 2013, 158:145-154
43. Sun Lichang, Fan Hongjie *, Wei Zuzhang *. Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability. Virus Research, 2013, 171:178- 185
44. Javed Memon, Yang Yongchun, Fan Hongjie*. Genotypes, Virulence Factors and Antimicrobial Resistance Genes of Staphylococcus aureus Isolated in Bovine Subclinical Mastitis from Eastern China, Pakistan veterinary journal, 2013, 33(4): 486-491
45. Lin Huixing, Ma Zhe, Fan Hongjie*. Construction and immunogenicity of recombinant swinepox virus expressing capsid protein of PCV2, Vaccine, 2012, 30:6307- 6313
46. Ma Zhe, Zhang Hui, Fan Hongjie*. Interaction between M-Like Protein and Macrophage Thioredoxin Facilitates Antiphagocytosis for Streptococcus equi ssp zooepidemicus, PLoS One, 2012, 7(2): e32099
47. Zhang Zhicheng, Fan Hongjie*, Lu Chengping. Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination, Archives of Virology, 2012, 157:927-933
48. Ma Zhe, Zhang Hui, Fan Hongjie*. Microarray Analysis of the Effect of Streptococcus equi subsp zooepidemicus M-Like Protein in Infecting Porcine Pulmonary Alveolar Macrophage, PLoS One, 2012, 7(5): e36452
49. Ma Zhe, Fan Hongjie*, Hu Songnian*. Complete Genome Sequence of Streptococcus equi subsp zooepidemicus Strain ATCC 35246, Journal of Bacteriology, 2011, 193(19):5583-5584
50. Lin Huixing, Huang Dongyan, Fan Hongjie*. A novel vaccine against Streptococcus equi ssp zooepidemicus infections: The recombinant swinepox virus expressing M-like protein, Vaccine, 2011, 29(40):7027-7034
51. Ma Zhe, Fan Hongjie*, Lu Chengping. Molecular cloning and analysis of the UDP-Glucose Pyrophosphorylase in Streptococcus equi subsp zooepidemicus, Molecular Biology Reports, 2011, 38(4):2751-2760
52. Zhang Zhicheng, Lu Chengping, Fan Hongjie*. Molecular characterization and epidemiological investigation of Pigeon circovirus isolated in eastern China. Journal of Veterinary Diagnostic Investigation, 2011, 23(4): 665-672
53. Mao Ying, Fan Hongjie*, Lu Chengping. Immunoproteomic Assay of Antigenic Surface Proteins in Streptococcus equi ssp. zooepidemicus. Agricultural Sciences in China, 2011, 10(7): 1096-1105
54. Zhang Hui, Fan Hongjie*, Lu Chengping. Identification of a Novel Virulence-Related Gene in Streptococcus suis Type 2 Strains, current microbiology, 2010, 61:494-499
55. Fan Hongjie*, Tang Fuyu, Lu Chengping. Virulence and antigenicity of the szp-gene deleted Streptococcus equi ssp. zooepidemicus mutant in mice, Vaccine, 2009, 27: 56-61
56. Jiang Hui, Fan Hongjie*, Lu Chengping. Identification and distribution of putative virulent genes in strains of Streptococcus suis serotype 2, Veterinary Microbiology, 2009, 133: 309-316
57.Mao Ying, Fan Hongjie*, Lu Chengping. Immunoproteomic assayof extracellular proteins inStreptococcusequi ssp.zooepidemicus, FEMS Microbiology Letters, 2008, 286:103-109
58. Fan Hongjie, Tang Fuyu, Lu Chengping*. Determination of the mimic epitope of the M-like protein adhesionin swine Streptococcus equi subsp. zooepidemicus, BMC Microbiology, 2008, 8(170): 1-9
