Teacher Name : Jianjun Dai
Job Title: Professor
Address：No.1 Weigang, Nanjing, Jiangsu 210095, P. R. China
Research Areas and Descriptors：
Preventive Veterinary Medicine, Veterinary Bacteriology
Mr. Dai graduated from Nanjing Agricultural University with a bachelor’s degree in 1991, and then obtained his Master's degree and PhD from Nanjing Agricultural University (NAU).
Since his professional career at NAU started in 1991, Mr. Dai served as the lecturer at College of Veterinary Medicine from 1996 to 2002, the associate professor for College of Veterinary Medicine from 2002 to 2010, and become the professor of NAU since 2010 and a doctoral advisor. In July 2011, Mr. Dai was appointed as a Vice President of Nanjing Agricultural University.
Moreover, Prof. Dai is also the vice director of National Steering Committee of Postgraduate Education for Veterinary Medicine Degree (VMD) and the vice president of China Entry & Exit Biosecurity Society.
Prof. Dai current research focuses on pathogenesis of bacteria, especially on Escherichia coli, which causes serious diseases both in human and animals all over the word. He leads a number of research projects funded by National Natural Science Foundation, Ministry of Science and Technology of China. His previous work includes pathogenesis, diagnosis, prevention and control of Escherichia Coli.
1) Focusing on developing new technology for diagnosis and detection of important avian-origin pathogenic bacteria. Supported with National Key R&D Program of China (Project 2016YFD0500804)
2) Study on the evolutionary mechanism of key biological characteristics of important infectious pathogenic bacteria. Supported by the National Basic Research Program of China (Project 973; 2015CB554200)
3) The molecular mechanisms for sRNA-mediated regulation facilitating Avian Pathogenic Escherichia coli intracellular macrophage survival. Supported by National Natural Science Foundation of China (grant no. 31672576)
4) The molecular mechanisms for macrophage injury induced by the critical effectors secreted from outer membrane vesicles (OMVs) of Avian Pathogenic Escherichia coli. Supported by National Natural Science Foundation of China (grant no. 31872479)
5) Research and demonstration of animal-origin Salmonellosis prevention and control technology. Supported by Chinese Special Fund for Agro-scientific Research in the Public Interest (201403054).
1. Xiangkai Zhuge, Yu Sun, Feng Xue, Fang Tang, Jianluan Ren, Dezhi Li, Juanfang Wang, Min Jiang and Jianjun Dai* (2018) A Novel PhoP/PhoQ Regulation Pathway Modulates the Survival of Extraintestinal Pathogenic Escherichia coli in Macrophages. Front. Immunol. 9:788. doi: 10.3389/fimmu.2018.00788
2. Dezhi Li, Fang Tang, Feng Xue, Jianluan Ren, Yun Liu, Dehong Yang, Jianjun Dai*. Prophage phiv142-3 enhances the colonization and resistance to environmental stresses of avian pathogenic Escherichia coli. Veterinary Microbiology 218 (2018) 70–77
3. Xiangkai Zhuge, Fang Tang, Hongfei Zhu, Xiang Mao, Shaohui Wang, Zongfu Wu, Chengping Lu, Jianjun Dai* & Hongjie Fan. AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection. [J]Sci. Rep. 6, 25085; doi: 10.1038/srep25085 (2016).
4. Xiang-kai Zhu-Ge, Zi-hao Pan, Fang Tang, Xiang Mao, Lin Hu, Shao-hui Wang, Bin Xu, Cheng-ping Lu, Hong-jie Fan, Jian-jun Dai*. The effects of upaB deletion and the double/triple deletion of upaB, aatA, and aatB genes on pathogenicity of avian pathogenic Escherichia coli. [J] Appl Microbiol Biotechnol.DOI 10.1007/s00253-015-6925-2
5. Fang Tang, Dezhi Li, Haojin Wang, Zhe Ma, Chengping Lu, Jianjun Dai*. Prophage Lysin Ply30 Protects Mice from Streptococcus suis and Streptococcus equi subsp. zooepidemicus Infections.[J]. Appl Environ Microbiol. 2015,81:7377–7384.
6. Shaohui Wang, YinliBao, QingmeiMeng, Yongjie Xia, Yichao Zhao, Yang Wang, Fang Tang, Xiangkai ZhuGe, Shengqing Yu, Xiangan Han, Jianjun Dai*,Chengping Lu*. IbeR Facilitates Stress-Resistance, Invasion and Pathogenicity of Avian Pathogenic Escherichia coli.[J]. Plos One, March 2015,10(3).
7. Shaohui Wang, Qingmei Meng, Jianjun Dai, Xiangan Han, Yue Han, Chan Ding, Haiwen Liu, Shengqing Yu*.Development of an Allele-Specific PCR Assay for Simultaneous Sero-Typing of Avian Pathogenic Escherichia coli Predominant O1, O2, O18 and O78 Strains[J].Plos One,May,2014,9(5):e96904.
8. Xiangkai Zhu Ge, Jingwei Jiang, Zihao Pan, Lin Hu, Shaohui Wang, Haojin Wang, Frederick C. Leung, Jianjun Dai*, Hongjie Fan. Comparative Genomic Analysis Shows That Avian Pathogenic Escherichia coli Isolate IMT5155 (O2:K1:H5; ST Complex 95, ST140) Shares Close Relationship with ST95 APEC O1:K1 and Human ExPEC O18:K1 Strains[J]. Plos One, 2014, 9:e112048-e112048.
9. Shaohui Wang, Jianjun Dai, Qingmei Meng, Xiangan Han, YueHan, Yichao Zhao, Denghui Yang, Chan Ding and Shengqing Yu*. DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli[J]. Frontier In Microbiology,2014, 5:588.
10. Xiangkai ZhuGe, Shaohui Wang, Hongjie Fan, Zihao Pan, Jianluan Ren, Li Yi, Qingmei Meng, Xuqiu Yang, Chengping Lu, and Jianjun Dai*.Characterization and Functional Analysis of AatB, a Novel Autotransporter Adhesin and Virulence Factor of Avian Pathogenic Escherichia coli [J].Infect.Immun. July 2013 81:7 2437-2447.
11. Shaohui Wang, Zhenyu Shi, Yongjie Xia, Huiqin Li, Yahui Kou, Yinli Bao, Jianjun Dai*, Chengping Lu*. IbeB is involved in the invasion and pathogenicity of avian pathogenic Escherichia coli [J]. Veterinary Microbiology. Volume 159, Issues 3-4, 12 October 2012, Pages 411-419.
12. Shaohui Wang, Yongjie Xia, Jianjun Dai, Zhenyu Shi, Yahui Kou, Huiqin Li, Yinli Bao & Chengping Lu*. Novel roles for autotransporter adhesion AatA of avian pathogenic Escherichia coli: colonization during infection and cell aggregation [J].FEMS Immunol Med Microbiol 63 (2011) 328-338.
13. Shaohui Wang, Chunling Niu, Zhenyu Shi, Yongjie Xia, Muhammad Yaqoob, Jianjun Dai*, and Chengping Lu* .Effects of ibeA deletion on the virulence and biofilm formation of an avian pathogenic Escherichia coli [J]. Infect.Immun. January2011; 79(1): 279-287.
14. Jianjun Dai, Shaohui Wang, D Guerlebeck,et al. Suppression subtractive hybridization identifies an autotransporter adhesion gene of E. coli IMT5155 specifically associated with avian pathogenic Escherichia coli (APEC)[J].BMC Microbiology.2010,10:236.