Basic Information
Teacher Name: Yang qian
Job Title: Professor
Phone: 13921430191
Email: zxbyq@njau.edu.cn
Address: Room 1020 Yifu building
Research Areas and Descriptors: Mucosal immunology
Profile
The majority of infections are transmitted at the mucosal surfaces and initial infection can only be prevented by mucosal immune responses.Our researches mainly focus on the mucosal immunology(Nasal and oral immunization) in domestic animals. The first field is mucosal adjuvants and delivery vehicles to enhance the local immunity. Some suitable mucosal adjuvants are being sought to improve the inactivated virus efficiency of local immunity. Some delivery vehicles(Lactobacillus isolated from chicken and pig, Bacillus subtilis)for antigens for oral immunization had been studied because of degradation of the antigen by gastric acid and proteases in the gastrointestinal tract.The second field focus on the interaction between the epithelium of host and enteric virus. Such as how the virus enter and invade host cell by adhesion、cell internalization、cytoskeleton disruption、interference of signaling pathways in their hosts. The transmission route mechanisms of enteric virus(such as porcine epidemic diarrhea virus) within pig are also studied.
Research projects
1. Study on effects of somatostatin on the modulation of mucosal immunization. (National Science Grant of China, 30070564) 2001-2003.
2. The study on the mechanism of PRRS immunization by mucosal rout. (Program of Jiangsu province in China. BK2002111)2002-2004.
3. The development and manufacture of complex adjuvants for mucosal immunization in chicken. (Program of Jiangsu province in China. BE2004318) 2004-2006.
4. Study on the expression of H5 Avian influenza hemagglutinin gene in Lactobacillus and its immunization efficacy. (Grant of educational ministry China, B200606) 2007-2009
5．Study on the mechanism of the S-layer proteins from lactobacilli against pathogens to enter host-cell. (National Science Grant of China, 30871858) 2008-2010.
6．The development and manufacture of complex adjuvants for avian influenza mucosal immunization in waterfowl. (Program of Jiangsu province in China. BE200830155) 2008-2010.
7. Study on the high efficiency of the intranasal immunization with inactivated avian influenza virus（National Science Grant of China, 31172302）2011-2015.
8. A newly mechanism for efficient promoting the intestinal immunity of newborn piglets.（National Science Grant of China, 31372465）2014-2018.
9. A novel pathway of PEDV dissemination within the host in newborn piglets（National Science Grant of China, 31772777）2018-2022.
List of Recent Publications
1.Yin Y, Qin T, Wang X, Lin J, Yu Q, Yang Q（corresponding author）: CpG DNA assists the whole inactivated H9N2 influenza virus in crossing the intestinal epithelial barriers via transepithelial uptake of dendritic cell dendrites.Mucosal Immunol. 2015, 8(4):799-814. (IF:7.5)
2.Tao Qin, Yinyan Yin, Qinghua Yu, Lulu Huang, Xiaoqing Wang, Jian Lin, Qian Yang（corresponding author）.CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa.Journal of Virology. 2015.89(11)：5904-5918 (IF:4.9)
3.Lu Xia, Lei Dai, Qinghua Yu, Qian Yang.（corresponding author） Persistent TGEV infection enhances ETEC K88 adhesion by promoting epithelial-mesenchymal transition in intestinal epithelial cells. J. Virol. doi:10.1128/JVI.01256-17 (IF:4.9)
4.Shan S Zhao, Qi Gao, Tao Qin , Yin Y Yina, Jian Lin, Qing H Yu, Qian Yang（corresponding author）.The effects of virulent and attenuated transmissible gastroenteritis virus on the ability of Porcine dendritic cells to sample and present antigen.Veterinary microbiology, 2014, 171(1-2):74-86. (IF:3.127)
5.Qi Gao, Shanshan Zhao, Tao Qin, Yinyan Yin, Jian Lin, Qinghua Yu, Qian Yang（corresponding author） Effects of porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cells.Veterinary Microbiology .2015. 179(3–4):131–141 (IF:3.127)
6.Xiaojuan Chen, Chongzhi Tu, Tao Qin, Liqi Zhu, Yinyan Yin & Qian Yang. （corresponding author） Retinoic acid facilitates inactivated transmissible gastroenteritis virus induction of CD8 + T-cell migration to the porcine gut. Scientific RepoRts | 6:24152 | DOI: 10.1038/srep24152 2016 IF:5.2)
7.Liqi Zhu , Chunxiao Mou , Xing Yang, Jian Lin and Qian Yang（corresponding author）. Mitophagy in TGEV infection counteracts oxidative stress and apoptosis. Oncotarget, Advance Publications 2016. (IF:6.1)
8.Jian Lin, Ya T. Chen, Jing Xia and Qian Yang .miR674 inhibits the neuraminidase-stimulated immune response on dendritic cells via down-regulated Mbnl3. Oncotarget, Advance Publications 2016. (IF:6.1)
9.Haofei Liu, Wenwen Xu, Xiaojing Chang，Tao Qin, Yinyan Yin and Qian Yang. （corresponding author）4,4’-diaponeurosporene, a C 30 carotenoid, effectively activates dendritic cells via CD36 and NF-κB signaling in a ROS independent manner. Oncotarget, 2016.Advance Publications (IF:6.1)
10.Yumeng Shen , Weiwei Hu , Yanna Wei , Zhixin Feng , Qian Yang（corresponding author）. Effects of Mycoplasma hyopneumoniae on porcine nasal cavity dendritic Cells. Veterinary Microbiology 198 (2017) 1–8 (IF:3.127)
11.Chunxiao Mou, Liqi Zhu, Xianping Xing, Jian Lin, Qian Yang（corresponding author）. Immune responses induced by recombinant Bacillus subtilis expressing the spike protein of transmissible gastroenteritis virus in pigs. Antiviral Research 131 (2016) 74e84. (IF:3.9)
12.Haofei Liu, Wenwen Xu, Qinghua Yu and Qian Yang（corresponding author）. 4,4′-Diaponeurosporene-Producing Bacillus subtilis increased Mouse resistance against Salmonella typhimurium infection in a cD36-Dependent Manner. Front. Immunol.2017. 8:483. doi: 10.3389/fimmu.2017.00483
13.Weiwei Hu , Liqi Zhu , Xing Yang, Jian Lin and Qian Yang（corresponding author）. The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells. Oncotarget, 2016. Vol. 7, No. 11
14.Chunxiao Mou, Liqi Zhu, Xianping Xing, Jian Lin, Qian Yang. Immune responses induced by recombinant Bacillus subtilis expressing the spike protein of transmissible gastroenteritis virus in pigs. Antiviral Research. 2016 (131)： 74-84
15.Yuchen Li , Guihua Wang , Jialu Wang , Kun Man , Qian Yang（corresponding author）.Cell attenuated porcine epidemic diarrhea virus strain Zhejiang08 provides effective immune protection attributed to dendritic cell stimulation. Vaccine. 2017, 35(50): 7033-7041.
16.Lu Xia, Lei Dai, Liqi Zhu, Weiwei Hu, Qian Yang（corresponding author）. Proteomic analysis of IPEC-J2 cells in response to coinfection by Porcine Transmissible Gastroenteritis Virus and Enterotoxigenic Escherichia coli. Proteomics - Clinical Applications. Proteomics Clin. Appl. 2017, 11, 1600137
17.Jian Lin , Jing Xia , Tian Zhang , Keyun Zhan , Qian Yang（corresponding author）. Genome-wide profiling of microRNAs reveals novel insights into the interactions between H9N2 avian influenza virus and avian dendritic cells. Oncogene.https://doi.org/10.1038/s41388-018-0279-z
