Basic Information
Teacher Name : Yuanshu Zhang
Job Title: professor
Phone：025-84396763
Email：zhangyuanshu@njau.edu.cn
Address：
Research Areas and Descriptors：Biochemistry and Molecular Biology
Profile
Personal Data
Sex: Female
Date of Birth: Aug.20th, 1962
Place of Birth: Yinchuan, Ningxia Hui Autonomous Region
Nationality: Chinese
Civil Status: Married
Health condition: Excellent
Education
2015- 2015 Visiting scholarship of milk biology laboratory, Vermont University, American from March to Septemper ,2015.
2006- 2007 Visiting scholarship of Peptide biology laboratory, Monash University, Melbourne, Australia
2000-2004 Ph.D.of Veterinary Medicine, Key Laboratory of Animal Physiology and Biochemistry，Ministry of Agriculture, basic veterinary College of veterinary medicine, Nanjing Agricultural University
1994-1997 Master of Veterinary Medicine, Key Laboratory of Animal Physiology and Biochemistry，Ministry of Agriculture, basic veterinary College of veterinary medicine, Nanjing Agricultural University
1979-1983 Bachelor of Veterinary Medicine, Ningxia Agricultural College
Employment Record and Research Experience
09/1983-09/1993 Having obtained my bachelor degree from Agricultural College of Ningxia, I joined the Laboratory of Biochemistry, Ningxia Agricultural school for a teacher of Animal Biochemistry (1983-1993).
09/1994-09/1997 I then joined Zousixiang group at the Laboratory of Peptides of Nanjing Agricultural University for my Master’s Degree (1994-1997). Then I returned to Ningxia Agricultural school and continued as a teacher of Animal Biochemistry.
09/1998-01/2015 In 1998, I transferred to Nanjing and worked at the Nanjing Agricultural University, and joined the Key Laboratory of Animal Physiology and Biochemistry，Ministry of Agriculture at the basic veterinary College of veterinary medicine, where I worked from 1998 to 2015. I obtained my Doctor’s Degree in 2004.
09/2006-09/2007 As a visiting scholarship, I worked at Peptide Biology Laboratory of Monash University in Australia. My teacher is Professor Ian Smith. At Ian’s Lab I joined the study of ACE2 including Separation and activity analysis of ACE2 from Brain and serum in sheep, I also found to detect some peptides of RAS.
03/2015-09/2015As a visiting scholarship, I worked at Milk Biology Laboratory of Vermont University in America. My teacher is Professor Fenqi Zhao. At zhao’s Lab I joined the study of Lactate experiment in MTC cell.
Iam now course head for the Animal Biochemistry subject at Nanjing Agricultural University where I also contribute to the teaching of Experimental Technique of Biochemistry and Molecular Biology. My research interests have included analysis of biological activity peptides from milk, mechanistic studies of peptides at the signal path and gene levels, milk protein and milk glucose biology of lactation animal. Effect and molecular mechanism of ACE2 in pig, goat and cows and so on.
Summary of Qualification
Research projects
2001 Participated the project “lumenal signal molecules ----the research of Casomorphin on influence endocrine and immunity of gut-gastric tract.” supported by National Natural Science Foundation of China, P. R. China.
2003 Preside over the project “the research on Antimicrobial Peptide Action” supported by Nanjing Agriculture University,
2004 Participated the project “Study of on Biological activity peptides, especially biology of opioid peptide（Casomorphin）derived from milk or food proteins.” supported by National Natural Science Foundation of China, P. R. China.
2006 Participated the project “Study of ACE2 in Australia” supported by Peptide Biology Laboratory of Monash University in Australia
2008 Presided the project “Expressing and adjusting Mechanism of angtensin converting Enzyme 2 (ACE2) in pituitary axis” supported by National Natural Science Foundation of China, P. R. China
2010-2015 Participated the “973” project “Milk Composition Precursors Redistribution Mechanism and Epigenetic Mechanism in Liver(grantnumber2011CB100802” supported by Ministry of Science and Technology of China, P. R. China
2017-2020, Participated the 13th Five-Year State Key Development Programproject “Digestive tract microbes regulate the structural carbohydrates of ruminants” (grantnumber2017YFD0500505 )supported by Ministry of Science and Technology of China, P. R. China
List of Recent Publications
1Wang K, Liu X, Xiao H, Wang H, Zhang Y. The correlation between inflammatory injury induced by LPS and RAS in EpH4-Ev cells, International Immunopharmacology, 2017, 46: 23–30.
2 Wang K, Xu Y, Yang W, Zhang Y. Insufficient hypothalamic Angiotensin- Converting Enzyme 2 is associated with hypertension in SHR rats, Oncotarget. 2017, 8(12): 20244-20251.
3Lin Li，Yang Cao ,Yuanshu Zhang* A High-Concentrate Diet Iinduced Milk Fat Decline via Gglucagon-Mmediated Aactivation of AMP- Activated Protein Kinase in Ddairy Cows, Scientific Report Production, 2017，
4 Zhenglu Xie, Xueyuan Jiang, Pingsheng Ye, Yuanshu Zhang *, Yingdong Ni, Su Zhuang, Xiangzhen Shen , The relationship between liver and low rumen pH in goat, Genet. Mol. Res. 14 (1): 209-221 (2015)
5 Xie, ZL (Xie, Z. L.); Ye, PS (Ye, P. S.); Zhang, YS (Zhang, Y. S.); Shen, XZ (Shen, X. Z.). Effect of high-concentrate diet on amino acid transporter expression and milk quality in Holstein dairy cows. Genetics and Molecular Research 14 (2): 5246-5257 (2015)
6 Zhang, W (Zhang, Wei); Song, SX (Song, Shangxin); Liu, F (Liu, Fei); Liu, Y (Liu, Yi); Zhang, YS (Zhang, Yuanshu), Beta-casomorphin-7 prevents epithelial-mesenchymaltransdifferentiation of NRK-52E cells at high glucose level: Involvement of AngⅡ-TGF-β1 pathway, peptide, Vol(70) : 37-44，2015
7 YuanyuanXu*, Tian Han, Xiaqing Li, Linghao Sun, Yujuan Zhang, Yuanshu Zhang**，Colorimetric detection of kanamycin based on analyte-protected silvernanoparticles and aptamer-selective sensing mechanism，AnalyticaChimicaActa(2015) 298-303
8 Ma C, Xin H, Jiang XY, Wang YX, Zhang YS，Relationship between renal injury and the antagonistic roles of angiotensin-converting enzyme (ACE) and ACE2， Genetics and Molecular Research ，Genet Mol Res. 2014 Apr 3;13(2):2333-42
9 X. Y. Jiang, Y. D. Ni, S. K. Zhang, Y. S.Zhang, and X. Z. Shen Identification of Differentially Expressed Proteins inLiver in Response to SubacuteRuminal Acidosis(SARA) Induced by High-concentrate Diet. Asian Australas. J. Anim. Sci. 2014; 27(8):1181-1188.
10 Han Dongning，zhangDonghui, Wang liping, Zhang Yuanshu, Protective effect of <beta>-Casomorphin-7 on cardiomyopathy of streptozotocin-induced diabetic rats via inhibition of hyperglycemia and oxidative stress，peptide，2013，page120-126
11 Wei Zhang, JingFeng MIAO, PengFei LI, YanXia Wang, YuanShu Zhang，Up-regulation of components of the renin–angiotensin system in liver fibrosisin the rat induced by CCL4,Research in Veterinary Science 95 (2013) 54–58
12 Wei Zhang, JingFeng MIAO, Shanshan Wang, YuanShu Zhang，The Protective Effects of beta-casomorphin-7 against Glucose -induced Renal Oxidative Stress in vivo and vitro, PLOS ONE, 2013 May 3;8(5):e63472. doi: 10.1371/journal.pone.0063472. Print 2013.
13 XueyuanJiang,YuanshuZhang,et al, Comparative proteomic and bioinformatic analysis of the effects of a high-grain diet on the hepatic metabolism in lactating dairy goats,PLOS ONE, 2013, 8(11): e80698. doi:10.1371/journal.pone.0080698
14 Yumin Zhu, Xiaoming Yu, Yuanshu Zhang, Yanyan Nid, Fusheng Sia, Ruisong Yua,Shijuan Donga,Yaowei Huangd, Zhen Lia,Infectivity of a genotype 4 hepatitis E virus cDNA clone by intrahepatic inoculation of laboratory rats，Volume 166, Issues 3–4, 25 October 2013, Pages 405–411 If=3.127
15 Haibo Dong1, Shaoqing Wang1, Yuanyuan Jia1, Yingdong Ni1*, Yuanshu Zhang1, Su Zhuang2,Xiangzhen Shen3, Ruqian Zhao1Long-Term Effects of SubacuteRuminal Acidosis (SARA)on Milk Quality and Hepatic Gene Expression inLactating Goats Fed a High-Concentrate Diet, PLOS ONE,2013
16 Hong Yin, Jinfeng Miao, Chang Ma, Yuanshu Zhang，Potential effects of β-casomorphin-7 in pancreas of type 1 diabetes rat，Journal of Food Science,77:(2); P278–282, 2012（ISSN 0022-1147,1.489,083201）
17Zhangwei, Miao jinfeng, Han Dongning, zhangyuanshu, <beta>-casomorphin-7 attenuates the development of nephropathy in type I diabetes via epithelial-mesenchymal transition of renal tubular epithelial cells,Peptides 36 (2012), pp. 186-191
18 Yin Hong, Miao jinfen,Zuangyuanshu Protective effect of β-casomorphin-7 inrats with streptozotocin-induced Type 1 diabetes，Peptide，2010,31(9):1725-1729
19 Liping Wang, Zhang Yuanshu*, Zhang Yuhan, Yaojie, Li Yingxia, Mutant prevention concentrations of fluoroquinolonesagainstCampylobacterjejuni isolated from chicken, Veterinary Microbiology,2010, 144 (2010) 409–414
20 Juan Chen, Xue Tang, Yuanshu Zhang, Haitian Ma*, SixiangZou.Effects of maternal treatment of dehydroepiandrosterone (DHEA) on serum lipid profile and hepatic lipid metabolism-related gene expression in embryonic chickens. Comparative Biochemistry and Physiology, part B , 2010, 155: 380-386.
21 Miao jingfen，zhangyuanshu，zousixiang et al, Polysaccharide Nucleic Acid of BacaillusCalmette Guerin Modulates Th1/Th2 Cytokine Gene Expression in Lipopolysaccharide-induced Mastitis in Rats.Chinese Agricultural Science，2009, 8 (8): 1010-1018
