Basic Information
Teacher Name: Liping Wang
Job Title: Professor
Phone:13739183092
Email:wlp71@163.com
Address:Yifu Building 2021, College of Veterinary Medicine,
Nanjing Agricultural University
Research Areas and Descriptors:
1. Mechanism of Bacteria Resistance
2. Drug Absorption and Transmembrane Transport
Profile
Education
Ph.D. Nanjing Agricultural University 2005 Veterinary Microbiology
M.S. Nanjing Agricultural University 1997 Veterinary Pharmacology and Toxicology
B. S. Nanjing Agricultural University 1994 Veterinary Medicine
Professional Experience
2010.1- pre: Professor, College of Veterinary Medicine, Nanjing Agricultural University.
2006.8-2007.8: Visiting Scholar, College of Veterinary Medicine, Iowa State University.
2005.1-2009.12: Associate Professor, College of Veterinary Medicine, Nanjing Agricultural University.
2000.1-2004.12: Lecturer, College of Veterinary Medicine, Nanjing Agricultural University
1997.6-1999.12: Teaching Assistant, College of Veterinary Medicine, Nanjing Agricultural University.
Professional Membership
Chinese Society for Microbiology
Chinese Society for Veterinary Pharmocology and Toxicology
Research Interest
Dr. Wang’s current research is focused on: 1) Establishing information systems on antimicrobial use and the emergence of bacterial resistance in animal population in China. In recent years, the related studies of the association between antibiotics exposure and the emergence of bacterial resistance as well as dissemination in animal population under different dosage regimen condition are carried out. The main pathogens include E. coli, Streptococcus suis and Enterococcus. 2) Pharmacodynamics and pharmacokinetics of novel drugs in carried out pigs and chickens. 3) The effects of ABC transporters on the drug disposition, especially on oral drug absorption in chickens and pigs.
Her research program involves undergraduate students, graduate students, postdoctoral researchers, and is supported by funds from the National Natural Science Foundation of China (NSFC), China Ministry of Science and Technology, and Nanjing Agricultural University.
Selected Funds (last 3 years)
2019-2022:Co-transmission and evolution of optrA-ermB involved in PhO-MLS resistance in Streptococcus suis(Supported by the National Natural Science Foundation of China, PI)
2018-2020: Novel Bacterial Resistance Mechanism (Supported by National Key Research and Development Program2018YFD0500300, PI)
2016-2020:BCS and Its Use in Veterinary Drugs Development (Supported by National Key Research and Development Program, 2018YFD0500300, PI)
2016-2019: The molecular mechanism of ICESa2603 family elements involved inhorizontal dissemination of ermB/tetO in Streptococcus suis (Supported by the National Natural Science Foundation of China, No.31572567, PI)
Published Paper(*Corresponding author, last 5 years)
1.Jinhu Huang, Li Chen, Daiwei Li, Mengli Wang, Yi Gao, Zuowei Wu*, Liping Wang*. Emergence of a vanG-carrying and multidrug resistant ICE in zoonotic pathogen Streptococccus suis. 2018, Veterinary Microbiology (Accepted)
2.Yujuan Zhang, Jinhu Huang,Yang Liu, Tingting Guo, Liping Wang*. Using the lentiviral vector system to stably express chicken P-gp and BCRP in MDCK cells for screening the substrates and studying the interplay of both transporters. 2018, Achieves of Toxicology, 92:2027–2042; doi.org/10.1007/s00204-018-2209-9
3.Tingting Guo, Jinhu Huang, Changchao Huan, Fang He, Yujuan Zhang, Zohaib A. Bhutto and Liping Wang*. Cloning and Transcriptional Activity Analysis of the Porcine Abcb1 Gene Promoter: Transcription Factor Sp1 Regulates the Expression of Porcine Abcb1. 2018, Fronteir in Pharmacology, doi: 10.3389/fphar.2018.00373
4.Zohaib Ahmed Bhutto, Fang He, Mire Zloh, Jing Yang, Jinhu Huang, Tingting Guo, Liping Wang *. Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken. 2018, Sci. Rep., 8:4400, DOI:10.1038/s41598-018-22354-1
5.Dawei Guo#, Dandan Dou#, Xinyu Li, Qian Zhang, Zohaib Ahmed Bhutto and Liping Wang*. Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour. Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46(2):255-262
6.Shamsuddin Bughio, Tingting Guo, Fang He, Yang Liu, Yang Song and Liping Wang*. Lipopolysaccharide Upregulating P-Glycoprotein in Small Intestine Alters Pharmacokinetics of Orally Administered Enrofloxacin in Broilers. Pak Vet J, 2017, 37(4): 399-404
7.Jinhu Huang, Li Chen, Zuowei Wu, Liping Wang *. Retrospective analysis of genome sequences revealed the wide dissemination of optrA in Gram-positive bacteria. Journal of Antimicrobial Chemotherapy, 2017, 72(2): 614-616.
8.Huang J, Ma J, Shang K, Hu X, Liang Y, Li D, Wu Z, Dai L, Chen L and Wang L*. Evolution and Diversity of the Antimicrobial Resistance Associated Mobilome in Streptococcus suis: A Probable Mobile Genetic Elements Reservoir for Other Streptococci. 2016, Front. Cell. Infect. Microbiol. 6:118. doi: 10.3389/fcimb.2016.00118
9.Tingting Guo, Jinhu Huang, Hongyu Zhang, Lingling Dong, Dawei Guo, Li Guo, Fang He, Zohaib Ahmed Bhutto, Liping Wang*. Abcb1 in Pigs: Molecular cloning, tissues distribution, functional analysis, and its effct on pharmacokinetics of enroflxacin.2016, Sci. Rep. 6, 32244; doi: 10.1038/srep32244
10.Mengjie Guo, Xiaohua Dai,Dongming Hu, Yu Zhang, Yong Sun, Weilong Ren, Liping Wang*. Potential Pharmacokinetic effect of rifampicin on enrofloxacin in broilers：Roles of P-glycoprotein and BCRP induction by rifampicin. 2016, Poultry Science, 95（9）： 2129-2135.
11.Yong Sun, Tingting Guo, Dawei Guo, Li Guo, Li Chen, Yu Zhang, Liping Wang* Establishment and Characterization of A MDCK Cell Line Stably-Transfected with Chicken Abcb1 Encoding P-glycoprotein. Research in Veterinary Science 106 (2016) 37-44
12.Huang J, Liang Y, Guo D, Shang K, Ge L, Kashif J and Wang L*. Comparative Genomic Analysis of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine Isolates in China. Front. Microbiol. 2016, 7:55. doi: 10.3389/fmicb.2016.00055
13.Dawei Guo, Dandan Dou, Lin Ge, Zhihai Huang, Liping Wang*, Ning Gu**. A caffeic acid mediated facile synthesis of silver nanoparticles withpowerful anti-cancer activity. Colloids and Surfaces B: Biointerfaces, 2015, 134 (2015) 229–234
14.Jinhu Huang, Kexin Shang, Jam Kashif and LipingWang*. Genetic diversity of Streptococcus suis isolated from three pig farms of China obtained by acquiring antibiotic resistance genes. J Sci Food Agric, 2015, 95(7):1454-1460 DOI 10.1002/jsfa.6841 (1.879)
15.Xiaolu Qian, Shang Kexin, Jam Kashif, Huang Jinhu and Wang Liping*. Dual efflux pumps satA and satB are associated with ciprofloxacin resistance in Streptococcus suis isolates. Pak Vet J, 2014, 34(4): 438-443
16.Jie Yao, Kexin Shang, Jinhu Huang, Wei Ran, Jam Kashif, Liping Wang*. Overexpression of an ABC transporter and mutations of GyrA, GyrB and ParC in contributing to high-level ciprofloxacin resistance in Streptococcus suis type 2. BioScience Trends 2014, 8(2):84-92
17.Zhangqi Shen, Taradon Luangtongkum, Zhiyi Qiang, Byeonghwa Jeon, Liping Wang, and Qijing Zhang. Identification of a Novel Membrane Transporter Mediating Resistance to Organic Arsenic in Campylobacter jejuni. Antimicro Agent and Chemothera, 2014, 58(4):2021-9
18.Mengjie Guo, Yong Sun, Yu Zhang, Shamsuddin Bughio, Xiaohua Dai Weilong Ren, Liping Wang*. E. coli Infection Modulates the Pharmacokinetics of Oral Enrofloxacin by Targeting P-Glycoprotein in Small Intestine and CYP450 3A in Liver and Kidney of Broilers. PLOS ONE, 2014, 9(1): e87781. doi:10.1371/journal.pone.0087781
19.Huang Jinhu, Yingxia Li, Kexin Shang, Jam Kashif, Xiaolu Qian and Liping Wang*. Efflux Pump, Methylation and Mutations in the 23S rRNA Genes Contributing to the Development of Macrolide Resistance in Streptococcus suis Isolated from Infected Human and Swine in China. Pakistan Veterinary Journal, 2014, 34(1):82-86
20.L. SU, L. DONG, S. BUGHIO, M. GUO, L. WANG*. Effect of colibacillosis or coccidiosis on expression of breast cancer resistance protein in small intestine and liver of chickens. J. Vet. Pharmacol. Ther. 2014, 37(1):53-58
21.Guo Mengjie, Shamsuddin Bughio, Sun Yong, Zhangyu, Dong Lingling, Wang Liping*. Age-related P-glycoprotein expression in the intestine and affecting the pharmacokinetics of orally administered enrofloxacin in broilers. PLOS ONE, 2013，8(9):e74150. doi:10.1371/journal.pone.0074150
22.Jam Kashif, Rehana Buriro, Javed Memon, Muhammad Yaqoob, Jamila Soomro, Diao Dongxue, Huang Jinhu and Wang Liping*. Detection of Class 1 and 2 Integrons, β-Lactamase Genes and Molecular Characterization of Sulfonamide Resistance in Escherichia coli Isolates Recovered from Poultry in China. Pak Vet J, 2013, 33(3):321-324
