Basic Information
Teacher Name: Dawei Guo(郭大伟)
Job Title: Associate professor
Phone:86-15996276221
Email:gdawei0123@njau.edu.cn
Address:1 Weigang, Nanjing 210095, China
Research Areas and Descriptors：
Lipid/polymer-based micro/nano delivery system
Synthesis and biomedical application of silver nanoparticles
Profile
EDUCATION
02/2015~07/2015
Advanced student in Pharmaceutics
School of pharmacy, China Pharmaceutical University, Nanjing, PR China
03/2010~11/2013
PhD student in Biomedical Engineering
School of Biology and Medical Engineering, Southeast University, Nanjing, PR China
09/2007~12/2009
MS student in Basic Veterinary Medicine
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, PR China
09/2003~12/2007
BS student in Veterinary Medicine
College of Animal Science and Technology, Anhui Agricultural University, Hefei, PR China
PROFESSIONAL EXPERIENCES
03/2017~03/2018
Visiting Scholar, College of Pharmacy, University of Nebraska Medical Center, USA
12/2015~now
AssociateProfessor, College of Veterinary Medicine, Nanjing Agricultural University
11/2013~12/2015
Lecturer, College of Veterinary Medicine, Nanjing Agricultural University
PUBLICATIONS
1) Gao Xiuge, Peng Lin , Ruan Xiangchun, Chen Xin, Ji Hui, Ma Junxiao, Ni Han, Jiang Shanxiang*,Guo Dawei*. Transcriptome profile analysis reveals cardiotoxicity of maduramicin in primary chicken myocardial cells.Archives of Toxicology2018. 92(3): 1267-1281
2) Guo Dawei#, Dou Dandan#, Li Xinyu, Zhang Qian, Zohaib Ahmed Bhutto, Wang Liping. Ivermectin-loaded solid lipid nanoparticles: preparation, characterization, stability and transdermal behavior. Artificial Cells, Nanomedicine, and Biotechnology2018. 46(2): 255-262.
3) Zhu Lingying#, GuoDawei#, SunLili, HuangZhihai, ZhangXiuyan, Ma Wenjuan, WuJie, XiaoLun, ZhaoYun, Gu Ning. Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells. Nanoscale 2017. 17(9): 5489-5498.
4) Tang Xuna#, GuoDawei#, Jiang Shanxiang, Gu Ning, Ni Yanhong, Ge Jiuyu,Hu Qingang. Facilepreparationofnanosilverparticleswithexcellentantimicrobialactivityviareleaseofionicsilver.Journal of Nanoscience and Nanotechnology2017, 17(2): 1046-1052.
5) Guo Dawei, Liu Guoyan, Li Xinyu, Tang Xuna, Zhang Junren, Zhu Xuewei, Jiang Shanxiang. A facile one-pot green synthesis and antibacterial activity of silver nanoparticles using lentinan from Lentinus edodes.Journal of Bionanoscience 2015, 9: 325-329.
6) Guo Dawei, Dou Dandan, Ge Lin, Huang Zhihai, Wang Liping, Gu Ning. A caffeic acid mediated facile synthesis of silver nanoparticles with powerful anti-cancer activity.Colloids and Surfaces B: Biointerfaces 2015, 134: 229-34.
7) Guo Dawei, Zhang Junren, Huang Zhihai, Jiang Shanxiang, Gu Ning. Colloidal silver nanoparticles improve anti-leukemic drug efficacy via amplification of oxidative stress.Colloids and Surfaces B: Biointerfaces2015, 126: 198-203.
8) Guo Dawei, Zhao Yun, Zhang Yu, Wang Qing, Huang Zhihai, Ding Qi, Guo Zhirui, Zhou Xuefeng, Zhu Lingying, Gu Ning. The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells.Journal of Biomedical Nanotechnology 2014, 10(4): 669-78.
9) Guo Dawei, Zhu Lingying, Huang Zhihai, Zhou Haixia, Ge Yue, Ma Wenjuan, Wu Jie, Zhang Xiuyan, Zhou Xuefeng, Zhang Yu, Zhao Yun, Gu Ning. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 2013, 34(32): 7884-94.
10) Guo Dawei#, Zhang Xiuyan#, Huang Zhihai, Zhou Xuefeng, Zhu Lingying, Zhaoyun, Gu Ning. Comparison of cellular responses across multiple passage numbers in Ba/F3-BCR-ABL cells induced by silver nanoparticles.Science China Life Sciences 2012, 55(10): 898-905.
11) Guo Dawei, Wang Liping, Lu Chengping, In vitro biofilm forming potential of Streptococcus suis isolated from human and swine in China, Brazilian Journal of Microbiology 2012, 43(3): 993-1004.
12) Guo Dawei, Zhu Lingying, Gu Ning, Progress on magnetic nanoparticles as gene delivery carrier (in Chinese), Materials China, 2013, 32(10): 553-558.
13) Gao Xiuge, Zheng Yani, Ruan Xiangchun, Ji Hui, Qiu Yawei, Liu Xiaoxiao, Teng Pei, Guo Dawei, Jiang Shanxiang. Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicology In Vitro2018, 50:190-200.
14) Gao Xiuge, Zheng Yani, Ruan Xiangchun, Ji Hui, Peng Lin, Guo Dawei, Jiang Shanxiang. Salinomycin induces primary chicken cardiomyocytes death via mitochondria mediated apoptosis.Chemico-Biological Interactions2018. 282: 45-54.
15) Ding Qi, Liu Dongfang, Guo Dawei, Yang Fang, Pang Xingyun, Che Renchao, Zhou Naizhen, Xie Jun, SunJianfei, Huang Zhihai, Gu Ning. Shape-controlled fabrication of magnetite silver hybrid nanoparticles with high performance magnetic hyperthermia. Biomaterials2017. 124: 35-46.
16) Ge Lin, Guo Dawei, He Fang,Huang Jinhu, Wang Liping. Resistance mechanism of Escherich ia coli mediated by PmrA-PmrB(in Chinese). Acta Veterinaria et Zootechnica Sinica2016, 47(4): 812-819.
17) Peng Lin, Guo Dawei, Zhang Wei, Ruan Xiangchun, Gao Xiuge, Gao Ying, Li Jiaojiao, Zheng Yani, Ji Hui, Jiang Shanxiang. Determination of chloramphenicols in the eels by UPLC－MS /MS(in Chinese). Animal Husbandry＆Veterinary Medicine 2016, 48(4): 30-35.
18) Sun Yong, Guo Tingting, Guo Dawei, Guo Li, Chen Li, Zhang Yu, Wang Liping. Establishment and characterization of a MDCK cell line stably-transfected with chicken Abcb1 encoding P-glycoprotein. Research in Veterinary Science2016, 106: 37-44.
19) Huang Jinhu, LiangYuan, Guo Dawei, Shang Kexin, Ge Lin, Kashif Jam, Wang Liping. Comparative genomic analysis of the ICESa2603 family ICEs and spread of erm(B)- and tet(O)-carrying transferable 89K-subtype ICEs in swine and bovine isolates in China. Frontiers in Microbiology 2016, 7: 55.
20) Ma Wenjuan, Liu Jian, Xie Jundan, Zhang Xiuyan, Zhou Haixia, Yao Hong, Zhang Weiqi, Guo Dawei, Zhu Lingying, Xiao Lun, Wu Depei, Xu Haiyan, Chen Suning. Zhao Yun. Modulating the growth and imatinib sensitivity of chronic myeloid leukemia stem/progenitor cells with pullulan/microRNA nanoparticles in vitro, Journal of Biomedical Nanotechnology2015, 11(11): 1961-1974.
21) Huang Zhihai, Jiang Hao, Liu Peidang, Sun Jianfei, Guo Dawei, Shan Jieling, Gu Ning. Continuous synthesis of size-tunable silver nanoparticles by green electrolysis method and multi-electrode design for high yield. Journal of Materials Chemistry A 2015, 3: 1925-1929.
22) Zhu Lingying, Guo Dawei, Gu Ning, Advances in in vitro detection of cytotoxicity induced by silver nanoparticles (in Chinese). China Science Bulletin (Chinese Version), 2014, 59(22): 2145-2152.
23) Zhou Xuefeng, Zhang Tianzhu, Guo Dawei, Gu Ning. A facile preparation of poly(ethylene oxide)-modified medical polyurethane to improve hemocompatibility. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2014, 441: 34-42.
24) Zhang Zubin, Song Lina, Dong Jinlai, Guo Dawei, Du Xiaolin, Cao Biyin, Zhang Yu, Gu Ning, Mao Xinliang. A promising combo gene delivery system developed from (3-aminopropyl)triethoxysilane -modified iron oxide nanoparticles and cationic polymers.Journal of Nanoparticle Research 2013, 15(5): 1659.
25) Huang Zhihai, Jiang Xiaoli, Guo Dawei,Gu Ning. Controllable synthesis and biomedical applications of silver nanomaterials.Journal of Nanoscience and Nanotechnology 2011, 11(11): 9305-9408.
CONFERENCE PRESENTATIONS
11/12/2017
“Synergistic therapeutic effect of novel microtubule destabilizer and hedgehog pathway inhibitor against chemoresistant prostate cancer (in English, poster presentation)” in 2017 AAPS Annual meeting and Exposition, San Diego, CA, USA
09/07/2017
“Synthesis and characterization of amphiphilic polymers PEG-p(TMC-BC) for micellar delivery of hedgehog pathway inhibitor MDB5 (in English, poster presentation)” in 4th Annual Biopharmaceutical Research and Development Symposium, Omaha, NE, USA.
22/10/2015
“The mechanism of silver nanoparticles-induced in Ba/F3 cells (in Chinese, oral presentation)” in 13th Academic Conference, Veterinary Pharmacology and Toxicology Branch of China Animal Husbandry and Veterinary Medicine, Changsha, PR China.
18/04/2015
“The cytotoxic effect of silver nanoparticles on myeloid leukemia cells(in Chinese, oral presentation)” in 8th Academic Conference, Basic Sciences Branch of Jiangsu Animal Husbandry and Veterinary Medicine, Jurong, PR China.
11/07/2012
“Comparison of cellular responses of different passages Ba/F3-BCR-ABL cells induced by silver nanoparticles(in Chinese, oral presentation)” in Doctoral Forum of Biological and Medical Nanotechnology (DFBMN2012’), Suzhou, PR China (Best Oral Award).
TEACHING EXPERIENCES
03/2014~now In College of Veterinary Medicine, Nanjing Agricultural University
• Taught Pharmaceutics to about 30 forth-year students majored in animal pharmacy and about 100 third-year students majored in animal medicine every year.
• Taught ‘Rational Use of Common Drugs in Clinic’ to about 100 students from various majors every term.
RESEARCH PROJECTS
01/2016~12/2020
“Study on new preparation and administration technology againstresistant bacteria”,National Key Research and Development Program (2016YFD0501306), ¥ 315,000
01/2016~12/2018
“The mechanism of autophagy in cytotoxicity induced silver nanoparticles”, the National Natural Science Foundation of China (31502120) and the Fundamental Research Funds for the Central Universities (KJQN201620), ¥ 300,000
09/2014~08/2017
“Preparation of silver nanoparticles loading cationic antimicrobial peptides and their antibacterial mechanism”, the Natural Science Foundation of Jiangsu Province in China (BK20140716), ¥ 200,000
ACADEMIC ASSOCITATION MEMBERSHIP
08/2017~now Member, American Association of Pharmaceutical Scientists
06/2010~now Member, ChineseSociety ofToxicology
07/2015~now Member, Chinese Society of Biomedical Engineering
AWARDS & HONORS
06/2016 Excellent instructor for undergraduate thesis (College)
11/2015Zhongshan Academic Rookie of Nanjing Agricultural University
11/2015Teaching Competition Award of College Young Teachers (third-class)
12/2014 Boehringer Ingelheim Awards for Teachers
