Basic Information
Teacher Name: Zhihai Lei
Job Title: professor
Phone: +86-25-84395294
Email: leizh@njau.edu.cn
Address: No.1 Weigang, Nanjing, 210095,
Jiangsu Province, P. R. China
Research Areas and Descriptors:
Animal anatomy; Animal neuroanatomy; neuropeptide and its
Receptors. Study newly-discovered neuropeptides and its receptors,
including their gene clonging, distribution and functions, especially
their roles in regulationg of animal reproduction and immunity.
Profile
1. Education
Sept, 1988 – July, 1991 Gansu Agricultural University, Doctor Degree, Veterinary Medicine
Sept, 1982 – July, 1985 Northwestern Agricultural University, Master Degree, Veterinary Medicine
Sept, 1978 – July, 1982 College of Northwestern Agriculture, Bachelor Degree, Veterinary Medicine
2. Work Experience
July, 1991 – now Nanjing Agricultural University, Professor
Sept, 1985 – Aug, 1988 Northwestern Agricultural University, Teaching assistant
3. Group Memberships
Vice chairman, Animal anatomy, Histology and Embriology Association, branch of Chinese Association of Animal Science and Veterinary Medicine(CAAV)
Member of Jiangsu Anatomy Association
Member of Chinese Anatomy Association
Publications
1. Zhiyu Ma, Ying Zhang, Juan Su, Sheng Yang, Wenna Qiao, Xiang Li, Zhihai Lei, Ling Cheng, Na An, Wenshao Wang, Yanyan Feng, Jinlong Zhang. Effects of neuromedin B on steroidogenesis, cell proliferation and apoptosis in porcine Leydig cells. Journal of Molecular Endocrinology, 2018 Apr 9. pii: JME-17-0242. doi: 10.1530/JME-17-0242.
2. Sheng Yang, Zhiyu Ma, Chuan Suo, Ling Cheng, Juan Su, Zhihai Lei. Cloning and mRNA expression of NPB and its effect on hormone secretion of the reproductive cells in the pig. General and comparative endocrinology. 2018, 261:97-103. doi: 10.1016/j.ygcen.2018.02.005. Epub 2018 Feb 23.
3. Zhiyu Ma，Ying Zhang，Juan Su，Xiang Li，Sheng Yang，Wenna Qiao，Chuan Suo，Zhihai Lei. Distribution of the Pig Gastrin-releasing Peptide Receptor and the Effect of GRP on Porcine Leydig Cells. Peptides, 2018,99:142-152.
4. Qiao Wenna, Wang Peiyong, Li Xiang, Ma Zhiyu, Su Juan, Lei Zhihai. Effects of neuromedin U on activity and function of porcine dendritic cells in vitro. Journal of Nanjing Agricultural University, 2017, 40(3):494-501
5. Li Xiaoliang, Li Xiang, Zhang Zheng, Lei Zhihai. Effects of neuromedin U on lymphocytes and nature killer cell activities of pig in vitro. Journal of Nanjing Agricultural University, 2017, 40(1):157-162
6. Xiang Li, Mingfu Niu, Juan Su, Zhiyu Ma, Mengmeng Jin, Wenna Qiao, Ying Zhang, Yanyan Feng, Na An,Yuanlong Hou, Sheng Yang, Suo Chuan, Zhihai Lei. Cloning and expression patterns of neuromedin U and its receptors in pigs. Neuropeptides. 2017，64：47-60.
7. Ma Zhiyu, Zhao Yangyang, Yao Yuan, Lei Zhihai, Jin Mengmeng, Li Xun, Jia Cuicui, Zhang Zheng, Li Xiang, Su Juan. Postnatal developmental of Neuromedin S and its receptor in the male Xiaomeishan pig reproductive axis. Anim Reprod Sci., 2017, 181:115-124.
8. Guo-Min Zhang, Ming-Tian Deng, Yan-Li Zhang, Yi-Xuan Fan, Yong-Jie Wan, Hai-Tao Nie, Zi-Yu Wang, Feng Wang, Zhi-Hai Lei. Effect of PGC-1α overexpression or silencing on mitochondrial apoptosis of goat luteinized granulosa cells. J Bioenerg Biomembr. 2016, 48(5):493-507.
9. Zhiyu Ma, Juan Su, Tingting Guo, Mengmeng Jin, Xiang Li, Zhihai Lei, Yuanlong Hou, Xiaoliang Li, Cuicui Jia, Zheng Zhang, Ejlal Ahmed. Neuromedin B and Its Receptor: Gene Cloning, Tissue Distribution and Expression Levels of the Reproductive Axis in Pigs. Plos One, 2016, 11(3):e0151871.
10. Rui Fang, Juan Su , Lucheng Zheng, Mengmeng Jin, Yuanlong Hou, Zhiyu Ma, Tingting Guo, Shenzheng Zhu, Xueli Ma, Ejlal Ahmed, Zhihai Lei. Cloning and distribution of neuropeptide W and its receptors in pigs. Research in veterinary science, 2015, 101:106-116
11. Ting-ting Guo, Juan Su, Zhi-yu Ma, Jun-xiao Ma, Meng-meng Jin, Xiang Li, Zhi-hai Lei. Cloning of neuromedin B and its receptor in the rabbit and generating a polyclonal antibody to the Neuromedin B protein. Gene, 2015, 564(1):21-8.
12. Hou Y, Wang X, Lei Z, Ping J, Liu J, Ma Z, Zhang Z, Jia C, Jin M, Li X, Li X, Chen S, Lv Y, Gao Y, Jia W, Su J. Heat Stress Induced Metabolic Changes and Altered Male Reproductive Function. J. Proteome Res, 2015, 14, 1495 - 1503
13. Lucheng Zheng, Juan Su, Rui Fang, Mengmeng Jin, Zhihai Lei, Yuanlong Hou, Zhiyu Ma, Tingting Guo. Developmental changes in the role of gonadotropin-inhibitory hormone (GnIH) and its receptors in the reproductive axis of male Xiaomeishan pigs. Anim Reprod Sci, 2015, 154:113-20.
14. WANG Yao，LI Xun，LI Min-jie，GUO Meng-jie，LEI Zhi-hai. Regulation of Gn IH on Reproduction of Female Pig. Scientia Agricultura Sinica，2014，47(18):3716-3724
15. ZHENG Lucheng，SU Juan，FANG Rui，JIN Mengmeng，MA Zhiyu，GUO Tingting，HOU Yuanlong，LEI Zhihai. Distribution and localization of gonadotropin-inhibitory hormone （GnIH) in the hypothalamus-pituitary-testis axis of boars. Journal of Nanjing Agricultural University，2014，37( 5) : 101－105
16. LEI Zhihai, LEI Ruipeng, Li Xiang, SU Juan, JIN Mengmeng. Advance in neuromedin U. Animal Husbandry ＆ Veterinary Medicine, 2014，46(7): 121-125
17. Yuan Yao, Juan Su, Fan Zhang, Zhihai Lei. Effect of central and peripheral administration of neuropeptide S on the level of serum proinflammatory cytokines in pigs. Neuroimmunomodulation, 2014, 21（1）: 45-51
18. LEI Ruipeng, GAO Qingsong, MA Zhiyu, GUO Tingting, MA Junxiao, LEI Zhihai. Advance in neuromedin B. Animal Husbandry ＆ Veterinary Medicine, 2013, 45（6）：87-91
19. Xun Li, Juan Su, Rui Fang, Lucheng Zheng, Ruipeng Lei, Xiaoye Wang, Zhihai Lei, Mengmeng Jin,Yang Jiao, Yuanlong Hou, Tingting Guo, Zhiyu Ma. The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro. Mol Cell Endocrinol., 2013，372（1-2）：65-72
20. Guo-Rui Zhang，Rui-Song Yu，Jiang-Yong Zeng，Yu-Min Zhu，Shi-Juan Dong，Luobu Dunzhu，Se Zhu，Ciren Duoji，Zhi-Hai Lei，Zhen Li. Development of an Epitope-Based Competitive ELISA for the Detection of Antibodies against Tibetan Peste des Petits Ruminants Virus. Intervirology, 2013, 56:55-59
21. SUN Xiao-xuan, LEI Zhi-hai, YANG Gui-hong, LIU Xin-yi, YE Ping. Gene cloning and distribution of neuropeptide W and its receptor 1 in rabbit. Scientia Agricultura Sinica，2012, 45（11）：2295-2305
22. Xun Li, Juan Su, Zhihai Lei, Yangyang Zhao, Mengmeng Jin, Rui Fang，Lucheng Zheng, Yang Jiao. Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle. Peptides, 2012, 36: 176-185
23. LEI Zhi-hai, LEI Rui-peng, SU Juan, JIA Xiao-qing. Advance in Xenin. Animal Husbandry ＆ Veterinary Medicine, 2012, 44(2): 97-101
24. Guihong Yang, Juan Su, Yuan Yao, Zhihai Lei, Guorui Zhang, Yanpeng Liu, Jing Liu, Xun Li. Distribution of neuromedin S and its receptor NMU2R in pigs. Research in Veterinary Science，2012，92：180-186.
25. HOU Yu-jing, LEI Zhi-hai, SU Juan, YAO Yuan, LI Yue-qin, YU Xiao-lei, LIU Qian. Study on the cloning and tissue expression of neuropeptide S and its receptor and effect of heat stress on their expression in the rabbit. Scientia Agricultura Sinica，2011，44（12）：2589-2600
26. Guo-rui Zhang, Jiang-yong Zeng, Yu-min Zhu, Shi-juan Dong, Se Zhu, Rui-song Yu, Ciren Duoji, Zhi-hai Lei, Zhen Li. Development of an Indirect ELISA with Artificially Synthesized N Protein of PPR Virus. Intervirology, 2012, 55:12-20
27. Yuan Yao, Juan Su, Guihong Yang, Guorui Zhang, Zhihai Lei, Fan Zhang, Xun Li, Rui Kou, Yanpeng Liu, Jing Liu. Effects of neuropeptide S on the proliferation of splenic lymphocytes, phagocytosis and proinflammatory cytokine production of pulmonary alveolar macrophages in the pig. Peptides, 2011, 32:118-12428. SU Juan, YAO Yuan, YANG Gui-hong, LI Xun, LIU Yan-peng, KOU Rui, LIU Jing, LEI Zhi-hai. Distribution of Orexin B in Porcine Hypothalamo-Pituitary-Gonadal Axis and the Regulation of Reproduction in Vitro. Chinese journal of animal and veterinary science, 2010, 41（11）：1460-1466
29. Guihong Yang, Juan Su, Yuan Yao, Zhihai Lei, Guorui Zhang, Xun Li. The regulatory mechanism of neuromedin S on luteinizing hormone in pigs. Animal Reproduction Science, 2010, 122:367-374
30. Ning Hong-mei, Ge Ya-ming, Su Juan, Zhang Wen-long, Yao Yuan, Yang Gui-hong, Lei Zhi-hai. Effects of orexin A on mRNA expression of various neuropeptides in the hypothalamus and pituitary, and on serum LH levels in ovariectomized gilts. Agricultural Sciences in China, 2010，9(9): 1362-1371
31. LIN Xiao-qin, YAO Yuan, ZHOU Ying-shan, BI Jing-shan, CUI Jin-xin, Zhou Chun-yan, LEI Zhi-hai. Expression and distribution of neuropeptide S and its receptor in pig immune organs. Animal Husbandry ＆ Veterinary Medicine，2010, 42（8）：57-62
32. LEI Zhi-hai, SU Juan, JIA Xiao-qing, LIU Yan-peng. Advances in neuropeptide W and neuropeptide B. Animal Husbandry ＆ Veterinary Medicine, 2010, 42（8）：94-99
33. Guihong Yang, Juan Su, Xun Li, Yuan Yao, Zhihai Lei, Xizhi Yang, Rui Kou, Yanpeng Liu. Expression of NMS and NMU2R in the pig reproductive axis during the estrus cycle and the effect of NMS on the reproductive axis in vitro. Peptides, 2009, 30: 2206-2212.
34. Yuan Yao, Xiaoqin Lin, Juan Su, Guihong Yang, Yujing Hou, Zhihai Lei. Cloning and distribution of neuropeptide S and its receptor in the pig. Neuropeptides, 2009, 43: 465-481
35. LI Yue, ZHU Xiang-lei, YANG Gui-hong, YANG Hong, YING Zhi-hao, YAO Yuan, SU Juan, LEI Zhi-hai. Distribution and developmental changes of ghrelin and its receptors in rabbit lymphatic organs. Animal Husbandry ＆ Veterinary Medicine, 2009, 41（7）: 63-66
36. LEI Zhi-hai, LI Yue, SU Juan, JIA Xiao-qing. Advance in the study of kisspeptin. Animal Husbandry ＆ Veterinary Medicine, 2009, 41（4）：96-100
37. LEI Zhi-hai, YANG Gui-hong, LI Yue-qin, HOU Yu-jing, YU Xiao-lei, LIU Qian. Advances in neuromedin S. Animal Husbandry ＆ Veterinary Medicine, 2009，41（3）：99-103
38. JIA Xiao-qing, TANG Tai-shan, HUANG Jin-hua, ZHANG Chang-yin, JU Shi-qiang, LEI Zhi-hai. Establishment of RT-PCR method for detection of equine influenza viruses. Animal Husbandry ＆ Veterinary Medicine, 2009, 41（2）：63-66
39. LEI Zhi-hai, LI Yue. Advances in gonadotropin-inhibitory hormone. Animal Husbandry ＆ Veterinary Medicine, 2008，40（9）：96-99
40. DENG Bi-hua, WANG Kai-min, TANG Tai-shan, ZHANG Chang-yin, LEI Zhi- hai. Establishment of nested PCR method for detection of bovine infectious rhinotracheitis virus. Chin J Vet Sci, 2008，28（6）：649-651
41. LEI Zhi-hai, YAO Yuan, LI Yue, YANG Gui-hong. Advances of neuropeptide S. Animal Husbandry ＆ Veterinary Medicine, 2008，40（5）：97-100
42. Wenlong Zhang, Zhihai Lei, Juan Su, Shulin Chen. Expression of ghrelin in the porcine hypothalamo–pituitary–ovary axis during the oestrous cycle. Animal reproduction Science, 2008，109：356-367
43. Juan Su, Zhihai Lei, Wenlong Zhang, Hongmei Ning, Jihui Ping. Distribution of orexin B and its relationship with GnRH in the pig hypothalamus. Research in Veterinary Science，2008，85：315-323
44. SU Juan, LEI Zhi-hai, NING Hong-mei, SONG Jie, JIA Cui-ping. Distribution of Orexin B in the Central Nervous System of Pig. Acta Veterinaria et Zootechnica Sinica, 2008, 39（3）：349-354
45. NING Hong-mei, LEI Zhi-hai, ZHANG Wen-long, SU Juan, JIA Cui-ping, SONG Jie, JIA Xiao-qing. Expression of preproorexin and OX1 R m RNA in the hypothalamo-pituitary-ovary axis of Suzhong sows in the oestrous cycle. Journal of Nanjing agricultural university, 2008, 31（1）：87-91
46. JIA Cui-Ping, LEI Zhi-Hai, NING Hong-Mei, SU Juan, ZHANG Wen-Long, JIA Xiao-Qing. Immunohistochemical Localization of Ghrelin containing Cells in the Chinchilla Rabbit. Chinese Journal of Zoology, 2007, 42(4) :129 – 134
47. CHEN Min, LEI Zhi-hai, SU Juan. Distribution of Orexin A-like immunoreactive neurons and nervous fibers in the brain and spinal cord of rabbit. Journal of Nanjing Agricultural University, 2006, 29 (4) : 102-106
48. CHEN Min, LEI Zhi-hai, SU Juan. Distribution of Orexin B-like Immunoreactive Fibers in the Central Nervous System of the Rabbit. Acta Veterinaria et Zootechnica Sinica, 2006, 37(8): 819-823
49. CHEN Min, LEI Zhi-hai, SU Juan. Localization of Orexin B-like Immunoreactive Neurons in Rabbit Brain. Chinese Journal of Zoology, 2006, 41(2) :53 - 57
