FACULTY

Hongjie Fan

Updated: 2018-09-20    Read:

Hongjie Fan           

 

Address:

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Tel:+86 25 84396219

Fax:+86 25 84396219

Email: fhj@njau.edu.cn

 

Positions Held:

President of the College of Veterinary Medicine, Nanjing Agricultural University

Professor of Preventive veterinary medicine, College of Veterinary Medicine, Nanjing Agricultural University

 

Education:

•   Ph.D. in Preventive veterinary medicine, College of Veterinary Medicine, Nanjing Agricultural University, 2003

•   M.S. in Preventive veterinary medicine, College of Veterinary Medicine, Yangzhou University, 1996

•   B.S. in Veterinary medicine, Anhui Science and TechnologyCollege, 1990

 

Research:

•Veterinary Microbiology and Immunology

•Veterinary Public Health

 

Awards:

•State Science and Technology Awards, the State Council, 2007

•TheState-level Teaching Award, the ministry of education, 2014

•Outstanding talents in agricultural scientific research, the Ministry of Agriculture, 2015

•TheJiangsu special Professor, the Jiangsu provincial government, 2013

 

Grant Proposals:

•National Key Research and Development Program of China, 2018-2020

•National Key Research and Development Program of China, 2017-2020

•National Natural Science Foundation of China, 2017-2020

•Special Fund for Agro-scientific Research in the Public Interest, 2014-2018

•National Transgenic Major Program, 2014-2016

•National Natural Science Foundation of China, 2013-2016

•National Basic Research Program (973) of China, 2012-2016

•National Natural Science Foundation of China, 2013-2015

•Jiangsu AgriculturalScience and Technology Innovation Fund, 2012-2014

•Jiangsu Province Science and Technology Support Program, 2009-2012

•National Transgenic Major Program, 2009-2011

•National Natural Science Foundation of China, 2008-2010

•National Natural Science Foundation of China, 2007-2007

 

Publications:

1. Liu Rui, Li Weiyi, Fan Hongjie*. The serine/threonine protein kinase of Streptococcus suis serotype 2 affects the ability of the pathogen to penetrate the blood brain barrier. Cellular Microbiology, 2018, 24:e12862

2. Ma Zhe, Yang Xinyi, Fan Hongjie*. Detection of Salmonella infection in chickens by an indirect enzyme-linked immunosorbent assay based on presence of PagC antibodies in sera. Foodborne Pathogens and Disease, 2017, 1(12)

3. Yuan Xiaomin, Lin Huixing, Fan Hongjie*. Swinepox virus vectorbased vaccines: attenuation and biosafety assessments following subcutaneous prick inoculation. Veterinary Research, 2018,49:14

4. Jiang Hui, Fan Hongjie, Ding Jiabo. Transcriptome analysis of gene expression profiling of infected macrophages between Brucella suis 1330 and live attenuated vaccine strain S2 displays mechanistic implication for regulation of virulence. Microbial Pathogenesis, 2018, 119:241–247

5. Zhu Yuanyuan, Fan Hongjie*, Zhao Qizu*. Insertion site of FLAG on foot-and-mouth disease virus VP1 G-H loop affects immunogenicity of FLAG. Journal of Integrative Agriculture 2018, 17: 60345-60357

6. Fan Hongjie*. Advances in pathogenesis of Streptococcus suis serotype 2. Journal of Integrative Agriculture, 2017, 16(12): 2834–2847

7. Xu Bin, Zhang Ping, Fan Hongjie*. hsdS, Belonging to the Type I Restriction-Modification System, Contributes to the Streptococcus suis Serotype 2 Survival Ability in Phagocytes. Frontiers in Microbiology, 2017, 8:1524

8. Yuan Xiaomin, Lin Huixing, Fan Hongjie*. Efficacy and immunogenicity of recombinant swinepox virus expressing the truncated S protein of the novel isolated porcine epidemic diarrhea virus strain. Archives of Virology, 2017, 7:1-11

9. Peng Jie, Ma Zhe, Fan Hongjie*. Virulent and vaccine strains of Streptococcus equi ssp. zooepidemicus have different influences on phagocytosis and cytokine secretion of macrophages. Journal of Proteome Research, 2017, 16:77-86

10. Ma Fang, Ma Zhe, Fan Hongjie*. Streptococcus suis Serotype 2 Biofilms Inhibit the Formation of Neutrophil Extracellular Traps. Frontiers in Cellular and Infection Microbiology, 2017, 7: 86

11. Ma Fang, Guo Xiao, Fan Hongjie*. Extracellular Nucleases of Streptococcus equi subsp. zooepidemicus Degrade Neutrophil Extracellular Traps and Impair Macrophage Activity of the Host. Applied and Environmental Microbiology, 2017, 83(2): e02468-16

12. Lin Huixing, Ma Zhe, Fan Hongjie*. Construction and immunogenicity of a recombinant swinepox virus expressing a multi-epitope peptide for porcine reproductive and respiratory syndrome virus. Scientific Reports, 2017, 7:43990

13. Lin Huixing, Li Bin, Fan Hongjie*. Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection. Journal of Proteome Research, 2017, 16: 2113-2120

14. Lin Huixing, Ma Zhe, Fan Hongjie*. Recombinant swinepox virus expressing glycoprotein E2 of classical swine fever virus confers complete protection in pigs upon viral challenge. Frontiers in Veterinary Science, 2017, 4:81

15. Wang Xiaomin, He Kongwang*, Fan Hongjie*. MicroRNA-30a-5p promotes replication of porcine circovirus type 2 through enhancing autophagy by targeting 14-3-3. Archives of Virology, 2017, 5:1-12

16. Liu Rui, Ma Zhe*, Fan Hongjie*. A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp zooepidemicus gene mutation. Scientific Reports, 2016, 6: 27133

17. Yi Li, Fan Hongjie*, Liu Chengping. Identification and characterization of a Streptococcus equi ssp. zooepidemicus immunogenic GroEL protein involved in biofilm formation. Veterinary Research, 2016, 47:50

18. Ma Zhe, Peng Jie, Fan Hongjie*. SILAC and LC-MS/MS identification of Streptococcus equi ssp. zooepidemicus proteins that contribute to mouse brain microvascular endothelial cell infection. Applied Microbiology and Biotechnology, 2016, 5: 1-12

19. Lin Huixing, Chen Lei, Fan Hongjie*. Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets against homologous challenge. Virology Journal, 2016, 13(68): 1-7

20. Xu Bin, Yang Xinyi, Fan Hongjie*. The arginine deiminase system facilitates environmental adaptability of Streptococcus equi ssp. zooepidemicus through pH adjustment. Research in Microbiology, 2016, 1-10

21. Xu Bin, Su Yiqi, Fan Hongjie*. Capsule of Streptococcus equi subsp zooepidemicus hampers the adherence and invasion of epithelial and endothelial cells and is attenuated during internalization. Fems Microbiology Letters, 2016, 363(16): 164

22. Zhuge Xiangkai, Dai Jianjun*, Fan Hongjie*. AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection. Scientific Reports, 2016; 6: 25085

23. Fang Yizhen, Lin Huixing, Fan Hongjie*. Construction and immunogenicity of recombinant swinepox virus expressing outer membrane protein L of Salmonella, Journal of Microbiology and Biotechnology, 2016, 26(1):1-13

24. Javed Memon, Jam Kashif, Fan Hongjie*, Serotypes, Genotypes, Virulence Factors and Antimicrobial Resistance Genes of Escherichia coli Isolated in Bovine Clinical Mastitis from Eastern China. Pakistan Veterinary Journal, 2016, 36(4):493-498

25. Yuan Xiaomin, Lin Huixing, Fan Hongjie*, Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein, Vaccine, 2015, 33:3900-3906

26. Ma Zhe, Yu Lei, Fan Hongjie*, Identification of novel genes expressed during host infection in Streptoccus equi ssp. zooepidemicus ATCC35246, Microbial Pathogenesis, 2015, 79:31-40

27. Hao Hongping, Hongjie Fan*, Xiang Mao*. LiCl inhibits PRRSV infection by enhancing Wnt/b-catenin pathway and suppressing inflammatory responses. Antiviral Research, 2015, 117: 99-109

28. Huan Changchao, Fan Hongjie*, Xiang Mao*, Porcine epidemic diarrhea virus uses cell-surface heparan sulfate as an attachment factor, Archives of Virology, 2015, 160:1621-1628

29. Ni Bo, HongJie Fan*, Xiang Mao*, The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry, Biochemical and Biophysical Research Communications, 2015, 458:392e398

30. Lin Huixing, Ma Zhe, Fan Hongjie*. A novel vaccine against Porcine circovirus type 2 (PCV2) and Streptococcus equi ssp. zooepidemicus (SEZ) co-infection, Veterinary Microbiology, 2014, 171(1-2):198-205

31. Zhang Hui, Fan Hongjie*, Lu Chengping*. The identification of six novel proteins with fibronectin or collagen type I binding activity from Streptococcus suis serotype 2, Journal of Microbiology, 2014, 52(11):963-969

32. Li Yue, Zheng Junxi, Fan Hongjie*. Effect of Tran on virulence through regulating metabolism and stress tolerance of Streptococcus suis serotype 2, Microbiology Research, 2014, 169(9):666-674

33. Yi Li, Wang Yang, Fan Hongjie*. Biofilm Formation of Streptococcus equi ssp. zooepidemicus and Comparative Proteomic Analysis of Biofilm and Planktonic Cells, Current Microbiology, 2014, 69(3):227-233

34. Ma Zhe, Fan Hongjie*, Hu Songnian*. Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp zooepidemicus strain ATCC35246, BMC Genomics, 2013, 14:1-12

35. Zhang Hui, Ma Zhe, Fan Hongjie*. Identification of a novel collagen type I-binding protein from Streptococcus suis serotype 2, The Veterinary Journal, 2013, 197(2):406-414

36. Yi Li, Wang Yang, Fan Hongjie*. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus equi ssp zooepidemicus, Pathogens and Disease, 2013, 67(3):174-183

37. Yi Li, Wang Yang, Fan Hongjie*. Identification of genes transcribed by Streptococcus equi ssp zooepidemicus in infected porcine lung, Microbial Pathogenesis, 2013, 59-60:7-12

38. Zhou Hong, Ma Zhe, Fan Hongjie*. Identification and Characterization of Putative Virulent Genes in Streptococcus equi ssp zooepidemicus, Journal of Integrative Agriculture, 2013, 12(2):327-333

39. Zheng Junxi, Li Yue, Fan Hongjie*. Identification and Characterization of a Novel Hemolysis-Related Gene in Streptococcus suis Serotype 2, PLoS One, 2013, 8(9)

40. Yang Yongchun, Fan Hongjie*, Lu Chengping. Molecular Characterization of Streptococcus agalactiae Isolated from Bovine Mastitis in Eastern China, PLOS ONE, 2013, 8(7)

41. Memon Javed, Wang Liping, Fan Hongjie*. Molecular Characterization and Antimicrobial Sensitivity of Pathogens from Sub-Clinical and Clinical Mastitis in Eastern China, Pakistan veterinary journal,  2013, 33(2):170-174

42. Zhang Zhicheng, Lu Chengping, Fan Hongjie*. Analysis of synonymous codon usage patterns in torque teno sus virus 1 (TTSuV1), Archives of Virology, 2013, 158:145-154

43. Sun Lichang, Fan Hongjie *, Wei Zuzhang *. Porcine reproductive and respiratory syndrome virus ORF5a protein is essential for virus viability. Virus Research, 2013, 171:178- 185

44. Javed Memon, Yang Yongchun, Fan Hongjie*. Genotypes, Virulence Factors and Antimicrobial Resistance Genes of Staphylococcus aureus Isolated in Bovine Subclinical Mastitis from Eastern China, Pakistan veterinary journal, 2013, 33(4): 486-491

45. Lin Huixing, Ma Zhe, Fan Hongjie*. Construction and immunogenicity of recombinant swinepox virus expressing capsid protein of PCV2, Vaccine, 2012, 30:6307- 6313

46. Ma Zhe, Zhang Hui, Fan Hongjie*. Interaction between M-Like Protein and Macrophage Thioredoxin Facilitates Antiphagocytosis for Streptococcus equi ssp zooepidemicus, PLoS One, 2012, 7(2): e32099

47. Zhang Zhicheng, Fan Hongjie*, Lu Chengping. Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination, Archives of Virology, 2012, 157:927-933

48. Ma Zhe, Zhang Hui, Fan Hongjie*. Microarray Analysis of the Effect of Streptococcus equi subsp zooepidemicus M-Like Protein in Infecting Porcine Pulmonary Alveolar Macrophage, PLoS One, 2012, 7(5): e36452

49. Ma Zhe, Fan Hongjie*, Hu Songnian*. Complete Genome Sequence of Streptococcus equi subsp zooepidemicus Strain ATCC 35246, Journal of Bacteriology, 2011, 193(19):5583-5584

50. Lin Huixing, Huang Dongyan, Fan Hongjie*. A novel vaccine against Streptococcus equi ssp zooepidemicus infections: The recombinant swinepox virus expressing M-like protein, Vaccine, 2011, 29(40):7027-7034

51. Ma Zhe, Fan Hongjie*, Lu Chengping. Molecular cloning and analysis of the UDP-Glucose Pyrophosphorylase in Streptococcus equi subsp zooepidemicus, Molecular Biology Reports, 2011, 38(4):2751-2760

52. Zhang Zhicheng, Lu Chengping, Fan Hongjie*. Molecular characterization and epidemiological investigation of Pigeon circovirus isolated in eastern China. Journal of Veterinary Diagnostic Investigation, 2011, 23(4): 665-672

53. Mao Ying, Fan Hongjie*, Lu Chengping. Immunoproteomic Assay of Antigenic Surface Proteins in Streptococcus equi ssp. zooepidemicus. Agricultural Sciences in China, 2011, 10(7): 1096-1105

54. Zhang Hui, Fan Hongjie*, Lu Chengping. Identification of a Novel Virulence-Related Gene in Streptococcus suis Type 2 Strains, current microbiology, 2010, 61:494-499

55. Fan Hongjie*, Tang Fuyu, Lu Chengping. Virulence and antigenicity of the szp-gene deleted Streptococcus equi ssp. zooepidemicus mutant in mice, Vaccine, 2009, 27: 56-61

56. Jiang Hui, Fan Hongjie*, Lu Chengping. Identification and distribution of putative virulent genes in strains of Streptococcus suis serotype 2, Veterinary Microbiology, 2009, 133: 309-316

57.Mao Ying, Fan Hongjie*, Lu Chengping. Immunoproteomic assayof extracellular proteins inStreptococcusequi ssp.zooepidemicus, FEMS Microbiology Letters, 2008, 286:103-109

58. Fan Hongjie, Tang Fuyu, Lu Chengping*. Determination of the mimic epitope of the M-like protein adhesionin swine Streptococcus equi subsp. zooepidemicus, BMC Microbiology, 2008, 8(170): 1-9