Updated: 2018-07-23    Read：

Basic Information

Teacher Name: Jihui Ping

Job Title:  Professor

Phone： 025-84396068-8042     

Email：jihui.ping@njau.edu.cn

Address：Institute of Immunology,

                  College of Veterinary Medicine

                  Nanjing Agricultural University

Research Areas and Descriptors：

(1) Explore the molecular basis of pathogenesis of influenza A virus.

(2) Development of high yield influenza viruses vaccine viruses.

(3) Elucidate the mechanism of antigenic drift for the influenza A viruses by selecting escape mutants in vitro and in vivo.

(4) Identification of subtype-specific epitopes in influenza A virus HAs.

(5) Explore the molecular basis of influenza A virus reassortant and assembly.

Publications:

• Jihui Ping,      Tiago J. S. Lopes, Gabriele Neumann, Yoshihiro Kawaoka, Development of      high-yield influenza B virus vaccine viruses, 2016, Proc Natl Acad Sci U S A      113:E8296-E8305.

• Chengjun      Li*, Masato Hatta*, David F. Burke*, Jihui      Ping*, Ying Zhang*, Makoto Ozawa, Andrew S. Taft, Subash C. Das,      Anthony P. Hanson, Jiasheng Song, Masaki Imai, Peter R. Wilker, Tokiko      Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A.      Russell, Sarah L. James, Eugene Skepner, Eileen A. Maher, Gabriele      Neumann, Alexander I. Klimov, Anne Kelso, John McCauley, Dayan Wang,      Yuelong Shu, Masato Tashiro, Nancy J. Cox, Derek J. Smith, and Yoshihiro      Kawaoka. Selection of antigenic variants representing a new cluster of      pandemic (H1N1) 2009 influenza viruses. Nature Microbiology, doi:      10.1038/nmicrobiol. 2016.58 (Co-first      author)

• Jihui Ping,      Tiago J. S. Lopes, Chairul A. Nidom, Elodie Ghedin, Catherine A. Macken,      Adam Fitch, Masaki Imai, Eileen A. Maher, Gabriele Neumann, Yoshihiro      Kawaoka. Development of high-yield influenza A virus vaccine      viruses. Nature Communications. 6:8148 doi: 10.1038/ncomms9148 (2015).

• Yuanlong      Hou, Xiaoyan Wang, Zhihai Lei,      Jihui Ping, jiajian Liu, Zhiyu Ma, Zheng Zhang, Cuicui Jia, Mengmeng      Jin, Xiang Li, Xiaoliang Li, Shaoqiu Chen, Yingfang Lv, Yingdong Gao, Wei      Jia, and Juan Su. Heat-Stress-Induced Metabolic Changes and Altered Male      Reproductive Function. J Proteome Res. 2015 Mar 6;14(3):1495-503. doi:      10.1021/pr501312t.

• Dankar SK, Miranda E, Forbes NE, Pelchat M,      Tavassoli A, Selman M, Jihui Ping, Jia J, Brown EG. Influenza      A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both      increase IFN antagonism, virulence and cytoplasmic localization but differ      in binding to RIG-I and CPSF30. Virol J. 2013 Jul 25;10:243. doi:      10.1186/1743-422X-10-243.

• Tokiko Watanabe, Maki Kiso, Satoshi Fukuyama, Noriko      Nakajima, Masaki Imai, Shinya Yamada, Shin Murakami, Seiya Yamayoshi,      Kiyoko Iwatsuki-Horimoto, Yoshihiro Sakoda, Emi Takashita, Ryan McBride,      Takeshi Noda, Masato Hatta, Hirotaka Imai, Dongming Zhao, Noriko Kishida,      Masayuki Shirakura, Robert P. de Vries, Shintaro Shichinohe, Masatoshi      Okamatsu, Tomokazu Tamura, Yuriko Tomita, Naomi Fujimoto, Kazue Goto,      Hiroaki Katsura, Eiryo Kawakami, Izumi Ishikawa, Shinji Watanabe, Mutsumi      Ito, Yuko Sakai-Tagawa, Yukihiko Sugita, Ryuta Uraki, Reina Yamaji, Amie      J. Eisfeld, Gongxun Zhong, Shufang Fan, Jihui Ping, Eileen A. Maher, Anthony Hanson, Yuko Uchida,      Takehiko Saito,     Makoto Ozawa,      Gabriele Neumann,     Hiroshi Kida,      Takato Odagiri, James C. Paulson,Hideki Hasegawa,Masato Tashiro&      Yoshihiro Kawaoka Characterization of H7N9 influenza A viruses isolated      from humans. Nature. 2013 Sep 26;501(7468):551-5. doi:      10.1038/nature12392.

• Jihui Ping, Mohammed Selman, Shaun Tyler, Nicole Forbes, Liya      Keleta, Earl Brown, Low pathogenic avian influenza      A/Turkey/Ontario/6213/1966(H5N1) is the progenitor of highly pathogenic      A/Turkey/Ontario/7732/1966(H5N9). Journal of General virology; 2012 Aug;      93 (Pt 8): 1649-57

• Nicole E. Forbes, Jihui Ping, Samar K.      Dankar, Jian-Jun Jia, Mohammed Selman, Liya Keleta, Yan Zhou, Earl G.      Brown, Multifunctional Adaptive NS1 Mutations Are Selected upon Human      Influenza Virus Evolution in the Mouse. 2012, PloS ONE, Volume 7 (2):      e31839

• Jihui Ping, L. Keleta, N. Forbes, S. Dankar, W. Stecho, S.      Tyler, Y. Zhou, L. Babiuk, H. Weingartl, R. A. Halpin, A. Boyne, J. Bera,      J. Hostetler, N. Fedorova, K. Proudfoot, D. Katzel, T.B. Stockwell, E.      Ghedin, D. Spiro and e. G. Brown, Genomic and Protein Structural Maps of      Adaptive Evolution of Human Influenza A Virus to Increased Virulence in      the Mouse. 2011, PLoS ONE, Volume 6(6): e217403.

• Samar K. Dankar, Shuai Wang, Jihui Ping,      Nicole E. Forbes, Liya Keleta, Earl G. Brown. Influenza A virus NS1 gene      mutations F103L and M106I increase replication and virulence. Virol J.      2011 Jan 12; 8(1):13

• Jihui Ping, Samar K. Dankar, Nicole E. Forbes, Liya Keleta,      Yan Zhou, Shaun Tyler Earl G. Brown, PB2 and HA Mutations are Major      Determinants of Host Range and Virulence in Mouse-Adapted Influenza A      Virus. Journal of virology. 2010, (84), 10606-10618.

• Jihui Ping, Chengjun Li, Guohua Deng, Yongping Jiang, Guobin      Tian, Shuxia Zhang, Zhigao Bu, Hualan Chen. Single-amino-acid mutation in      the HA alters the recognition of H9N2 influenza virus by a monoclonal      antibody. Biochem. Biophys.Res. Commun. 2008, (371):168-171

• Chengjun Li, Jihui Ping, Bo Jing, Guohua      Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu,      Hualan Chen. H5N1 influenza marker vaccine for serological differentiation      between vaccinated and infected chickens. Biochem. Biophys. Res. Commun.      2008, (372): 293-297

• Juan Su, Zhihai Lei, Wenlong Zhang, Hongmei Ning, Jihui      Ping. Distribution of orexin B and its relationship with GnRH in the      pig hypothalamus. Research in Veterinary Science. 2008,(85): 315-323

• Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu,      Liling Liu, Bo Jing, Jihui Ping, Hualan Chen. Evolution of H9N2      influenza viruses from domestic poultry in Mainland China. Virology. 2005 Sep 15;340(1):70-83.

Patents:

·         Influenza virus replication for vaccine development, Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. Patent NO.: US9890363

·         High titer recombinant influenza viruses with enhanced replication in MDCK or Vero cells or Eggs. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. Publication NO.: US/2017/0354730

·         Influenza B viruses replication for vaccine development. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. Publication NO.: US/2017/0258888

·         Influenza virus replication by inhibiting microRNA Let-7C binding to influenza viral cRNA and mRNA. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. Publication NO.: US/2016/0355790.

·         Mutations in the influenza A virus NS1 gene and use thereof. Inventors: E. G Brown, Nicole Forbes and Jihui Ping. US patent, publication NO.: US 2011/0070254.