Basic Information
Teacher Name: Endong Bao
Job Title: Professor
Phone: 025-84395316
Email: b_endong@njau.edu.cn; baoed@ringpu.com
Address: Room 2027,Yifu Building
Research Areas and Descriptors: Immunopathology and molecular pathology
Profile
En-dong Bao, born in December 1963, professor and doctoral supervisor in College of Veterinary Medicine, Nanjing Agricultural University, acts as the executive director of International Society for Animal Health (ISAH), member of Standardization technical committee of Chinese Veterinary Medical Association, member of ChineseSlaughter Processing Standardization Technical Committee, executive director of Veterinary Pathology Branch of Chinese Animal Husbandry and Veterinary Society, and holds concurrentlythe executive vice President of research institute in Tianjin Ringpu Bio-Technology Co., Ltd. and theexpertof Tianjin Technology System of Dairy Industry.
From 1979 to 1983,he studied as an undergraduate student in the Department of Animal Husbandry and Veterinary Medicine in Ningxia Agricultural College and joined the school as a teaching assistant after graduation.He studied for a MasterDegree of veterinary pathology in Inner Mongolia College of Agriculture and Animal Husbandry from 1985 to 1988, and returned to work as the teaching assistant and lecturer in the Department of Husbandry and Veterinary Medicine of Ningxia Agricultural College. He studied inNanjing Agricultural Universityfor a DoctorDegree of veterinary pathology andgot a position as lecturer, associate professor and professorseparately in the College of Veterinary Medicine, Nanjing Agricultural Universityafter graduatedin 1995.He studied in the department of biology of Konstanz University and Hanover University of Veterinary Medicine, Germany from 1999 to 2000,from 2001 to 2002 and from 2004 to 2005, respectively. Devoted to study on mycoplasmal pneumonia of swine, animal tumor investigation, rabbit viral hemorrhagic disease, chicken infectious bursa disease, embryo immunity of chicken marek's disease, and animal stress protein and the pathogeneticmechanism of stress injury. Act as the chief editor of 《Animal Pathology》, and deputy chief editor of 《Sanitary Inspection of Animal Products》; coedited 《Veterinary Pathology》, 《Animal Pathology》,《Pathophysiology of Livestock》and《Pathological Anatomy of Livestock》.Research projects is mainly involvedin heat shock protein and stress damage, andthe research and development of new veterinary drug.He published more than 190 research papers in domestic and foreign core journals, therein more than 50 papers have been published in foreign key SCI journals.
Research projects:
1. Hosted the National Natural Science Foundation Project "the expression pattern of heat shock proteins and its molecular mechanism to resist stress injury in transport-stressed pigs" (30972165), 2010-2012.
2. Hosted the sub-project of theSpecial Scientific Research Project forPublic WelfareIndustry (Agriculture) of the Ministry of Agriculture"The response and regulation technology on environmental stress in livestock production and transportation",(201003060-11), 2010-2014.
3. Hosted the Doctoral Program Project of the Ministry of Education (the category of doctoral supervisor) "the mechanism of BCG-PSN to intervenesignal transduction and apoptosis in immune cells " (20100097110007), 2011-2013.
4. Hosted the Research Projectof School-Enterprise Cooperation"pre-clinical and clinicalstudy of the new veterinary drugs: the bulk drug of tilmicosin phosphate and the soluble powder of tilmicosin phosphate", 2011-2012.
5.Hosted the Sino-German Agricultural Science and Technology Cooperation Project"The detection and prevention of microorganisms (including zoonotic pathogens) from air source and fine dust in intensive animal production environment and surrounding" (42/04-05chn20) and "the correlation study of environmental stress andthe expression of heat shock proteins in pig organs and rat cell models" (29/08-09chn21), 2012-2013.
6. Hosted the Research Projectof School-Enterprise Cooperation"the application and development of a new veterinary drug: the bulk drug of chymoprotease and trypsin, and the breast injection of compound protease", 2012-2013.
7. Hosted the sub-project of National Key Basic Research Development Plan (973 program), "The physiology and related genetic regulation mechanismon pig breeding" (2014CB138502), 2014-2018.
8. Hosted the National Natural Science Foundation Project "the molecular mechanism of over-expressed heat shock protein to resiststress injury of myocardial cells" (31372403), 2014-2017.
9. Hosted the National Natural Science Foundation Project "theeffect of Hspsexpression and post-translational modification on the resistance of chicken cardiomyocytes to heat stress damage" (31672520), 2017-2020.
Honors:
The project "the molecular mechanism of stress-induced myocardial injury and resisting stress injury by inducing expression of heat shock proteins" wonthe second prize of Natural Science Prize of the ministry of education(2016) and the second prize of Natural Science Prize of education scientific research award inJiangsu province (the category of science and technology research in university ) (2016).
Patent:
1. A polynucleotide microcapsule for treating diseases in livestock and poultryand its preparation method;Nanjing Agricultural University, Nanjing Nongda new veterinary medicine development engineering technology Co., LTD.A inventionpatent;Bao Endong, lvYingjun, Su Jiandong;Authorization number: ZL200910028167.8;Awarding time: 2011.01.26.
2. The oral BCG-PSNliposomesmodified by the derivative of amylopectinand its freeze-dried preparations for livestock.Nanjing Agricultural University, Nanjing Nongda new veterinary medicine development engineering technology Co., LTD.Ainvention patent;Bao Endong, Wang Xiaobin;Authorization number: ZL201010242300.2;Awarding time: 2011.11.23.
The representative papers:
1. Miao Zhang, Zhenhua Yue, Zhijun Liu, Ali Islam, BuriroRehana, Shu Tang, Endong Bao, JörgHartung，Hsp70 and HSF-1 expression is altered in the tissues of pigs transported for various periods of times，Journal of Veterinary Science，2012，13(3), 253-259.
2. Jochen Schulz, Endong Bao, Marcus Clauβ, JörgHartung, The potential of a new air cleaner to reduce airborne microorganisms in pig house air: preliminary results, Berliner und MünchenerTierärztlicheWochenschrift，2013，126 (3/4): 143-148.
3. Shu Tang，RehanaBuriro, Zhijun Liu, Miao Zhang, Islam Ali, Abdelnasir Adam, JörgHartung, Endong Bao*，Localization and Expression of Hsp27 and aB-Crystallin in Rat Primary Myocardial Cells during Heat Stress In Vitro，PLoS ONE，2013，8（7）：e69066. doi:10.1371/journal.pone.0069066.
4.Shu Tang, Jimian Yu, Miao Zhang, Endong Bao*. Effects of different heat stress periods on various blood and meat quality parameters in young Arbor Acer broiler chickens，Canadian Journal of Animal Science，2013，93（4）：453-460.
5. Shu Tang，YinjunLv#, Hongbo Chen, Abdelnasir Adam, Yanfen Cheng, JörgHartung, Endong Bao*，Comparative analysis of αB-Crystallin expression in heat-stressed myocardial cells in vivo and in vitro，PLOS ONE，2014，9（1）：e86937. doi:10.1371/journal.pone.0086937
6,Hongbo Chen, Abdelnasir Adam, Yanfen Cheng, Shu Tang, J. Hartung, Endong Bao*, Localization and expression of heat shock protein 70 with rat myocardial cell damage induced by heat stress in vitro and in vivo, MolecularMedicine Reports，2015，11: 2276-2284
7, Di Wu, Jiao Xu, Erbao Song, Shu Tang, Xiaohui Zhang, N. Kemper, J. Hartung and Endong Bao*, Acetyl salicylic acid protected against heat-stress damage in chicken myocardial cells and may associate with induced Hsp27 expression，Cell Stress and Chaperone，2015，20（4）：687-696.
8,Shu Tang，JörgHartung, Endong Bao*，The expression profiles of Hsp27 and αB-crystallin and their relationship in heat-stressed rat myocardial cells in vitro and in vivo，MolecularMedicine Reports，2016，13: 1633-1638.
9,Shu Tang，Hongbo Chen, YanfenCheng, Mohammad Abdel Nasir, Nicole Kemper，Endong Bao*，The interactive relationship between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress，International Journal of Molecular Medicine，2016，37（1）: 56-62.
10,Xiaohui Zhang, Huaisen Zhu, Zhuang Qian,Shu Tang，Di Wu, Nicole Kemper，JörgHartung, Endong Bao *. The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells, The Journal of Veterinary Science, 2016, 17（1）：35-44.
11, Di Wu, Miao Zhang，Jiao Xu，Erbao Song，YingjunLv, Shu Tang，Xiaohui Zhang，N.Kemper，JörgHartung, Endong Bao*，In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells，Cell Stress and Chaperone，2016，21（3）：405-413.
12,Xiaohui Zhang, Zhe Wang, Bing Yin，Hong Wu，Shu Tang，Lei Wu，Yanan Su, Ye Lin，Xiqian Liu，Bo Pang，Nicole. Kemper，JörgHartung, Endong Bao *，A complex of trypsin and chymotrypsin effectively inhibited growth of pathogenic bacteria inducing cow mastitis and showed synergistic antibacterial activity with antibiotics，Livestock Science，2016，188：25-36.
13,Ruicheng Wei, Feng Ge, Lili Zhang, Xiang Hou, Yinan Cao, Lan Gong, Ming Chen, Ran Wang, Endong Bao. Occurrence of 13 veterinary drugs in animal manure-amended soils in Eastern China, Chemosphere, 2016, 144: 2377-2383.
14,Xiaohui Zhang, Zhuang Qian, Huaisen Zhu,Shu Tang，Di Wu，Nicole. Kemper，JörgHartung, Endong Bao*，HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress，British Poultry Science, 2016，57（4）: 462 - 473.
15, Di Wu, Miao Zhang，YingjunLv, Shu Tang，Nicole.Kemper，JörgHartung, Endong Bao*，Aspirin-induced heat stress resistance in chicken myocardial cells can be suppressed by BAPTA-AM in vitro，Cell Stress and Chaperone，2016，21(5), 817-827 (DOI：10.1007/s12192-016-0706-4)
16,YanfenCheng, Jiarui Sun, Hongbo Chen, Abdelnasir Adam, Shu Tang, Nicole Kemper，JörgHartung and Endong Bao*，Expression and location of HSP60 and HSP10 in the heart tissue of heat-stressed rats，Experimental and Therapeutic Medicine，2016，12: 2759-2765.
17,Erbao Song，Shu Tang，Jiao Xu，Bin Yin，Endong Bao，JörgHartung，Lenti-siRNA Hsp60 promote bax in mitochondria and induces apoptosis during heat stress，Biochemical and Biophysical Research Communications，2016，481:125-131.
18,HuaisenZhu, Zhuang Qian, HonglinLiu, Endong Bao.ACTH-induced stress in weaned sows impairs LH receptor expression and steroidogenesis capacity in the ovary. Reproductive Biology and Endocrinology, 2016, 14(1):80.
19, Shu Tang, Bin Yin, Erbao Song, Hongbo Chen, Yanfen Cheng, Xiaohui Zhang, Endong Bao, HartungJorgerg. Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens. Scientific Report. 2016 Nov 18;6:37273.
20, Jiao Xu, Shu Tang, Erbao Song, Bin Yin, Endong Bao. Inhibition of heat shock protein 70 intensifies heat-stressed damage and apoptosis of chicken primary myocardial cells in vitro. Molecular Medicine Reports, 2017, 15(5):2881-2889.
21, Bin Yin, Shu Tang,Jiarui Sun, XiaohuiZhangi, Jiao Xu, Liangjiao Di, ZhihongLi, YurongHu, Endong Bao.Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress.Cell Stress Chaperones. 2018, 23(4):735-748.
